FEM Analysis of Tablet Hardness and Punch Strength Using ANSYS Software
FEM Analysis of Tablet Hardness and Punch Strength Using ANSYS Software
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使用 ANSYS 软件对片剂硬度和冲切强度进行 FEM 分析
DOI：
10.1299/jcst.5.120
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
H. Furuichi
中科院分区：
文献类型：
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作者：
Hideaki Sato;T. Miura;H. Furuichi
片剂是当今市场上最常见的剂型。它们有许多不同的形状、颜色和味道。人们有时会发现吞咽药片很困难，我们已经报道过曲率半径较小的药片更容易吞咽。然而，小的曲率半径倾向于导致片剂硬度降低。另一方面，压片机上产生的大量应力可能会使冲头断裂。冲压强度有简单的设计手册，但没有详细描述计算方法。我们使用ANSYS软件对片剂硬度和冲头强度进行了有限元分析。然后将冲压反作用力转录为片剂杨氏模量（转录模型）。以干酵母为例，ANSYS模拟结果与实验结果吻合较好。采用响应面法研究了凸模形状与许用载荷的关系，计算了凸模形状对许用载荷的贡献。
Tablets are the most common dosage forms found in the market today. They come in many different shapes, colors and flavors. People sometimes find it difficult to swallow tablets, and we have reported that tablets with a smaller radius of curvature are easier to swallow. However, a small radius of curvature tends to result in decreased tablet hardness. On the other hand, a lot of stress occurring on the tablet press may break the punch head. There are simple design manuals of punch strength, however no computational method has been described in detail. We performed an FEM analysis of tablet hardness and punch strength using ANSYS software. The punch reaction force was then transcribed as the tablet Young's modulus (the transcription model). The result of ANSYS simulation in a tablet made from dry yeast was consistent with the experimental result. In addition, the relation between punch shape and allowable load was studied employing the Response Surface Method and the punch shape contribution for allowable load was calculated.