Stable aqueous dispersions of carbon nanohorns loaded with minocycline and exhibiting antibacterial activity
Stable aqueous dispersions of carbon nanohorns loaded with minocycline and exhibiting antibacterial activity
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DOI：
10.1016/j.carbon.2020.04.040
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发表时间：
2020-09
期刊：
影响因子：
10.9
通讯作者：
Yukari Maeda;E. Hirata;Yuta Takano;N. Sakaguchi;Natsumi Ushijima;A. Saeki;Sadahito Kimura;K. Shibata;M. Yudasaka;A. Yokoyama
中科院分区：
文献类型：
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作者：
Yukari Maeda;E. Hirata;Yuta Takano;N. Sakaguchi;Natsumi Ushijima;A. Saeki;Sadahito Kimura;K. Shibata;M. Yudasaka;A. Yokoyama
这项工作表明，某些医学上批准的药物具有双重功能，即它们表现出内在的药物效应，并有助于分散碳纳米材料。以米诺环素（MC）为分散剂，成功地将两种类型的碳纳米角（cnh）（未氧化：as- cnh，氧化：CNHox550）和碳纳米管（CNTs）分散在水溶液中。吸收光谱、热重分析和理论计算表明，在这些分散体中，MC附着在cnh上。用变形链球菌和放线菌聚集菌对这些MC/CNH复合物的抑菌活性进行了检测，发现MC/as-CNH复合物与原MC保持相同的细菌生长抑制活性。我们的研究结果表明，药物/纳米碳复合物在药物递送方面具有潜在的应用前景。
This work demonstrates that certain medically-approved drugs possess dual functions such that they exhibit intrinsic drug effects and can assist in dispersing carbon nanomaterials. Two types of carbon nanohorns (CNHs) (unoxidized: as-CNH, oxidized: CNHox550) and carbon nanotubes (CNTs) were successfully dispersed in aqueous solutions using minocycline (MC) as a dispersant. Absorption spectra, thermogravimetric analyses and theoretical calculations demonstrated that the MC was attached to the CNHs in these dispersions. The antibacterial activities of these MC/CNH complexes were examined usingStreptcoccus mutansandAggregatibacter actinomycetemcomitans, and the MC/as-CNH complex was found to maintain the same bacterial growth inhibition activity as the original MC. Electron microscopy observations suggested direct contact of the MC/CNH complexes with the bacteria, presumably allowing delivery of the MC. The results obtained from our study demonstrate that drug/nanocarbon complexes have potential applications in drug delivery.