Waning Immunity Against Respiratory Syncytial Virus During the Coronavirus Disease 2019 Pandemic
Waning Immunity Against Respiratory Syncytial Virus During the Coronavirus Disease 2019 Pandemic
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DOI：
10.1093/infdis/jiac192
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发表时间：
2022-05-07
影响因子：
6.4
通讯作者：
Lavoie, Pascal M.
中科院分区：
文献类型：
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作者：
Reicherz, Frederic;Xu, Rui Yang;Lavoie, Pascal M.
在2019年冠状病毒病(新冠肺炎)大流行的第一年，卫生司法管辖区的呼吸道合胞病毒几乎消失。在此期间，我们报告了加拿大不列颠哥伦比亚省(BC)2020年5月至6月和2021年2月至6月期间育龄妇女和婴儿血清中RSV抗体水平和活病毒中和水平的下降。这支持了对RSV的抗体免疫相对短暂，维持婴儿的最佳抗体水平需要反复接触母亲的病毒。免疫力下降可能解释了不列颠哥伦比亚省和其他国家观察到的呼吸道合胞病毒病例的季节性回升。本文显示，在新冠肺炎相关社会疏远措施的背景下，育龄妇女和婴儿血清中和呼吸道合胞病毒抗体下降，这可能解释了世界其他地区呼吸道合胞病毒病例非典型的反季节回升。
Health jurisdictions have seen a near-disappearance of respiratory syncytial virus (RSV) during the first year of the coronavirus disease 2019 (COVID-19) pandemic. Over this corresponding period, we report a reduction in RSV antibody levels and live virus neutralization in sera from women of childbearing age and infants between May to June 2020 and February to June 2021, in British Columbia (BC), Canada. This supports that antibody immunity against RSV is relatively short-lived and that maintaining optimal antibody levels in infants requires repeated maternal viral exposure. Waning immunity may explain the interseasonal resurgence of RSV cases observed in BC and other countries.This article shows decreased serum RSV antibody neutralization in women of childbearing age and infants in the context of COVID-19-related social distancing measures, which may have explained the atypical, off-season resurgence of RSV cases in other areas of the world.