Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year follow-up of the prospective Basel Study.
Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year follow-up of the prospective Basel Study.
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前瞻性巴塞尔研究 12 年随访中的血浆抗氧化维生素和随后的癌症死亡率。
DOI：
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发表时间：
1991
影响因子：
5
通讯作者：
Georg Brubacher
中科院分区：
文献类型：
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作者：
H. B. Stähelin;K. Gey;Monika Eichholzer;E. Lüdin;F. Bernasconi;Jacqueline Thumeysen;Georg Brubacher
在1971-1973年参加前瞻性巴塞尔研究第三次检查的2,974名男性中，测量了血浆抗氧化维生素A、C、E和胡萝卜素。1985年，对所有参与者的生命状态和死亡率进行了评估。共有204名男子死于癌症，其中68人死于支气管癌，37人死于胃肠癌（20人死于胃癌，17人死于大肠癌，不包括直肠癌）。癌症的总死亡率与调整胆固醇后的胡萝卜素（p <0.01）和维生素C（p <0.01）的平均血浆水平低有关。支气管癌和胃癌与低平均血浆胡萝卜素水平相关（p <0.01）。随后患胃癌的受试者的平均维生素C和血脂调整的维生素A水平也低于幸存者（p <0.05）。在使用考克斯模型计算相对风险并排除随访前2年的死亡率后，低血浆胡萝卜素（低于四分位数1）与支气管癌风险显著增加相关（相对危险度（RR）= 1.8，p <0.05），所有癌症患者血浆胡萝卜素和维生素A水平均较低（RR = 2.47，p <0.01），以及老年肺癌患者（年龄大于60岁）的低血浆视黄醇（RR = 2.17，p <0.05）。低水平的维生素C增加了老年受试者患胃癌（RR = 2.38）和胃肠道癌（RR = 2.46）的风险，但仅在前2年才显着增加。作者得出结论，血浆抗氧化维生素水平低与随后癌症死亡率的风险增加有关。这种影响在血液采样时年龄超过60岁的男性中更强，并且这种影响似乎具有部位特异性。
Plasma antioxidant vitamins A, C, and E and carotene were measured in a group of 2,974 men participating in the third examination of the prospective Basel Study in 1971-1973. In 1985, the vital status and mortality of all participants were assessed. A total of 204 men had died from cancer, including 68 with bronchus cancer and 37 with gastrointestinal cancer (20 with stomach cancer and 17 with large bowel cancer excluding cancer of the rectum). Overall mortality from cancer was associated with low mean plasma levels of carotene adjusted for cholesterol (p less than 0.01) and of vitamin C (p less than 0.01). Bronchus and stomach cancers were associated with a low mean plasma carotene level (p less than 0.01). Subjects with subsequent stomach cancer also had lower mean vitamin C and lipid-adjusted vitamin A levels than did survivors (p less than 0.05). After calculation of the relative risk using the Cox model with exclusion of mortality during the first 2 years of follow-up, low plasma carotene (below quartile 1) was associated with a significantly increased risk for bronchus cancer (relative risk (RR) = 1.8, p less than 0.05), low plasma levels of carotene and vitamin A with all cancers (RR = 2.47, p less than 0.01), and low plasma retinol in older subjects (greater than age 60 years) with lung cancer (RR = 2.17, p less than 0.05). Low levels of vitamin C increased the risk of stomach cancer (RR = 2.38) and gastrointestinal cancer (RR = 2.46) in older subjects, but only significantly with the inclusion of the first 2 years. The authors conclude that low plasma levels of antioxidant vitamins are associated with an increased risk of subsequent cancer mortality. This effect was stronger in men above age 60 years at blood sampling, and the effect seems to be site-specific.