HLA-C locus alleles in patients with psoriatic arthritis (PsA)
HLA-C locus alleles in patients with psoriatic arthritis (PsA)
复制标题
DOI：
10.1016/s0198-8859(98)00123-2
复制
发表时间：
1999-03-01
期刊：
影响因子：
2.7
通讯作者：
Wade, JA
中科院分区：
文献类型：
--
作者：
Gladman, DD;Cheung, C;Wade, JA
本研究的目的是比较银屑病关节炎患者和正常人群中人类白细胞抗原C等位基因的频率，并探讨人类白细胞抗原基因与银屑病关节炎(PSA)疾病表型的关系。1996年4月至7月在前列腺特异性抗原(PSA)诊所就诊的94名患者和100名无病对照进行了血清学和分子技术的HLA配型。根据标准方案对患者的疾病进行评估。用Fisher‘s精确检验比较患者组和对照组的等位基因频率。用聚合酶链式反应-单链构象多态方法检测的HL A-C使患者和对照组中未识别的“空白”(或零)等位基因的频率降低到6%。在32名患者和18名对照组中发现了HLA-Cw*0602：等位基因频率在患者组为17%，对照组为9%(p<；0.01)。在银屑病关节炎患者中，携带人类白细胞抗原-Cw0602等位基因的患者银屑病的平均发病年龄显著提前(P=0.003)。本研究证实了分子DNA技术提高了C基因座等位基因的检测水平。与对照组相比，银屑病关节炎患者的HLA-CW*0602基因增加。人类白细胞抗原-CW*0602与银屑病发病年龄较早有关。《人类免疫学》60,259-261(1999)。(C)美国组织相容性和免疫遗传学学会，1999年，爱思唯尔科学公司出版。
The aim of this investigation was to compare the frequency of alleles at the HLA-C locus in patients with psoriatic arthritis to that in the disease free population and to relate the HLA genes to disease phenotype in psoriatic arthritis (PsA). Ninety-four consecutive patients seen in the (PsA) clinic between April and July 1996 and 100 disease-free controls had HLA typing performed by both serologic and molecular techniques. Patients' disease was assessed according to a standard protocol. Fisher's exact test was used to compare the frequency of HLA alleles in the patients and controls. HLA-C determined by PCR-SSP decreased the frequency of non-identified, that is, "blank" (or null) alleles to 6% in patients and controls. HLA-Cw*0602 was present in 32 patients and 18 controls: allele frequency of 17% in the patients Versus 9% in the controls (p < 0.01). Amongst patients with psoriatic arthritis, those who carried the HLA-Cw*0602 allele had a significantly earlier mean age of onset of their psoriasis (P = 0.003). This study confirms that molecular DNA techniques improve detection of C-locus alleles. The HLA-Cw*0602 is increased amongst patients with psoriatic arthritis compared to controls. The HLA-Cw*0602 is associated with an earlier age of onset of psoriwis. Human Immunology 60, 259-261 (1999). (C) American Society for Histocompatibility and Immunogenetics, 1999 Published by Elsevier Science Inc.