Lymphoproliferative disorders in cardiac transplant recipients are multiclonal lymphomas.
Lymphoproliferative disorders in cardiac transplant recipients are multiclonal lymphomas.
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心脏移植受者的淋巴增殖性疾病是多克隆淋巴瘤。
DOI：
10.1016/s0140-6736(84)92566-2
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Sklar,J
中科院分区：
文献类型：
--
作者：
Cleary,ML;Sklar,J
对5例免疫抑制心脏移植受者淋巴组织增生性疾病的组织标本进行了免疫球蛋白DNA重排检查。在每种情况下，从几个地点或在不同的时间获得的组织的DNA分析显示不同的克隆免疫球蛋白基因重排的三个免疫球蛋白基因位点。这些发现表明，免疫抑制心脏移植受者的淋巴组织增生性疾病代表多克隆或寡克隆B细胞淋巴瘤。
Tissue specimens from 5 immunosuppressed cardiac transplant recipients with lymphoproliferative disorders were examined for rearrangements in immmunoglobulin DNA. In each case DNA analysis of tissues obtained from several sites or at various times showed different clonal immunoglobulin gene rearrangements for each of the three immunoglobulin gene loci. These findings indicate that lymphoproliferative disorders in immunosuppressed cardiac transplant recipients represent multiclonal or oligoclonal B cell lymphomas.