Protective cross-reactive epitope on the nonstructural protein NS1 of influenza A virus.
Protective cross-reactive epitope on the nonstructural protein NS1 of influenza A virus.
复制标题
甲型流感病毒非结构蛋白 NS1 上的保护性交叉反应表位。
DOI：
10.1089/vim.1993.6.229
复制
发表时间：
1993
期刊：
影响因子：
2.2
通讯作者：
Ennis,FA
中科院分区：
文献类型：
--
作者：
Saikh,KU;Tamura,M;Kuwano,K;Dai,LC;West,K;Ennis,FA
We reported previously that adoptive immunization with an influenza A virus NS1-specific H-2Ld-restricted, cross-reactive, CTL clone A-ll established by stimulation with A/PR/8/34 virus (H1N1) reduced lung virus titers in mice challenged with virus in vivo (Virology 178:174–179,1990). Using a set of recombinant vaccinia virus constructs containing truncated portions of the NS gene we have localized this cross-protective CTL epitope to the N-terminal region of the NS1 protein. This region of NS1 is active in inducing CD8+CTLin vivobecause virus-stimulated BALB/c immune spleen cells in bulk cultures also recognized the N-terminal region of the NS1 protein.
