Cortical representations of personally familiar objects and places: Functional organization of the human posterior cingulate cortex
Cortical representations of personally familiar objects and places: Functional organization of the human posterior cingulate cortex
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DOI：
10.1162/0898929053124956
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发表时间：
2005-02-01
影响因子：
3.2
通讯作者：
Fink, GR
中科院分区：
文献类型：
--
作者：
Sugiura, M;Shah, NJ;Fink, GR
对个人熟悉的物体和地点的再认都涉及非空间记忆提取过程，但只有个人熟悉的地方才被表征为空间。尽管后扣带回(PCC)被认为处理这两种类型的记忆，但它的功能组织却鲜为人知。在这项与事件相关的fMRI研究中，正常被试将熟悉/不熟悉的图片分为四类：熟悉的地方(FP)、熟悉的物体(170)、不熟悉的地方(UP)和不熟悉的物体(UO)，从而构成了一个双因素设计。在双侧颞枕顶内侧的几个区域，包括尾侧PCC区(CPCC)和海马区旁回，观察到位置刺激(Fp和Up)比客体刺激(FO和UO)激活更大的显著主效应。反向比较显示两侧枕颞部外侧下交界处和顶内沟有较大的激活。熟悉试验(FP和FO)比陌生试验(UP和UO)有显著的主效应，即熟悉的MPCC、脾后皮质、后楔前叶和左侧顶内沟的激活程度高于不熟悉的(UP和UO)试验。仅在右背背侧PCC(PPCC)观察到FP试验的特异性激活(通过相互作用进行评估)。结合以往功能成像研究的数据，结果表明，人类PCC在个人熟悉的地方的空间表征中存在不同的参与，而在个人熟悉的地点和物体的情景提取中，MPCC和脾后皮质的功能分离。左侧顶叶内沟的激活可能反映了与物体操作相关的记忆的恢复。
The recognition of both personally familiar objects and places involves nonspatial memory retrieval processes, but only personally familiar places are represented as space. Although the posterior cingulate cortex (PCC) is considered to process both types Of Such memories, its functional organization is poorly understood. In this event-related fMRI study, normal subjects judged familiar/unfamiliar pictures in four categories: familiar places (FP), familiar objects (170), unfamiliar places (UP), and unfamiliar objects (UO), thus constituting a two-factorial design. A significant main effect of stimuli with greater activation in the place (FP and UP) than object (FO and UO) trials was observed bilaterally in several medial temporo-occipito-parietal regions, including the caudal PCC (cPCC) and parahippocampal gyrus. The reverse comparison revealed greater activation in the lateral inferior occipito-temporal junctions and intraparietal sulci bilaterally. A significant main effect of familiarity with greater activation in the familiar (FP and FO) than unfamiliar (UP and UO) trials was observed in the mid-dorsal PCC mPCC, retrosplenial cortex, posterior precuneus, and the left intraparietal sulcus. Activation specific to the FP trials (as assessed by the interaction) was observed in the right posterodorsal PCC (pPCC) only. Together with data from previous functional imaging studies, the results suggest a functional segregation of human PCC with differential involvement of pPCC in spatial representations of personally familiar places and of the mPCC and retrosplenial cortex in episodic retrieval of personally familiar places and objects. Activation of the left intrapariltal sulcus may reflect retrieval of memories related to object manipulation.