Effective control of dengue vectors with curtains and water container covers treated with insecticide in Mexico and Venezuela: cluster randomised trials
Effective control of dengue vectors with curtains and water container covers treated with insecticide in Mexico and Venezuela: cluster randomised trials
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DOI：
10.1136/bmj.332.7552.1247
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发表时间：
2006-05-27
影响因子：
105.7
通讯作者：
McCall, P. J.
中科院分区：
文献类型：
--
作者：
Kroeger, Axel;Lenhart, Audrey;McCall, P. J.
Objectives to measure the impact on dengue vector population（Aedes aegypti）and disease transmittance of window curtains and water container coveres treated with insecticid.Design Cluster randomized controlled trial based on entomological survey and，for特鲁希略only，serological survey.此外，每个网站有一个非随机的外部控制。设置18个城市部门在韦拉克鲁斯州（墨西哥）和18个在特鲁希略（委内瑞拉）。参与者4743居民（1095房屋）在韦拉克鲁斯州和5306居民（1122房屋）在特鲁希略。干预部门根据昆虫学指数配对，并在每对一个部门被随机分配接受治疗。在韦拉克鲁斯州，干预措施包括用三氟氯氰菊酯处理窗帘和用吡丙醚片（一种昆虫生长调节剂）处理水。在特鲁希略，干预措施包括使用长效溴氰菊酯（PermaNet）处理的窗帘和相同材料的水罐盖。随访调查进行了间隔，最后一次调查后12个月在韦拉克鲁斯州和9个月在特鲁希略。主要结果措施减少昆虫学指数，特别是Breteau和房子indices.Results在这两个研究地点，在试验结束时的指数显着低于基线，虽然没有显着差异控制和干预武器。平均Breteau指数从60%（干预组）和113%（对照组）下降到7%（干预组）和12%（对照组），韦拉克鲁斯中部从38%下降到11%（干预组），特鲁希略从34%下降到17%（对照组）。人均感染量和容器指数显示了类似的模式。相反，在附近的社区，没有在试验中，昆虫指数遵循降雨模式。干预措施减少了邻近控制集群中的蚊子种群（溢出效应）;距离受处理房屋较近的房屋比距离较远的房屋更不可能受到侵扰。这产生了一种社区效应，使整个研究地点的蚊子数量减少。观察到的效果可能与使用杀虫剂处理的材料在这两个网站，因为在韦拉克鲁斯州，人们不接受和使用吡丙醚chiproxyfen芯片。结论窗帘和家用水容器盖处理杀虫剂可以降低登革热媒介的密度到较低的水平，并可能影响登革热的传播。
Objectives To measure the impact on the dengue vector population (Aedes aegypti) and disease transmission of window curtains and water container covers treated with insecticide.Design Cluster randomised controlled trial based on entomological surveys and, for TruJillo only, serological survey. In addition, each site had a non-randomised external control.Setting 18 urban sectors in Veracruz (Mexico) and 18 in Trujillo (Venezuela).Participants 4743 inhabitants (1095 houses) in Veracruz and 5306 inhabitants (1122 houses) in Trujillo.Intervention Sectors were paired according to entomological indices, and one sector in each pair was randomly allocated to receive treatment. In Veracruz, the intervention comprised curtains treated with lambdacyhalothrin and water treatment with pyriproxyfen chips (an insect growth regulator). In Trujillo, the intervention comprised curtains treated with longlasting deltamethrin (PermaNet) plus water jar covers of the same material. Follow-up surveys were conducted at intervals, with the final survey after 12 months in Veracruz and nine months in Trujillo.Main outcome measures Reduction in entomological indices, specifically the Breteau and house indices.Results In both study sites, indices at the end of the trial were significantly lower than those at baseline, though with no significant differences between control and intervention arms. The mean Breteau index dropped from 60% (intervention clusters) and 113% (control) to 7% (intervention) and 12% (control) in Veracruz mid from 38% to 11% (intervention) and from 34% to 17% (control) in Trujillo. The pupae per person and container indices showed similar patterns. hi contrast, in nearby communities not in die trial die entomological indices followed the rainfall pattern. The intervention reduced mosquito, populations in neighbouring control clusters (spill-over effect); and houses closer to treated houses were less likely to have infestations than those further away. This created a community effect whereby mosquito numbers were reduced throughout the study site. The observed effects were probably associated with the use of materials treated with insecticide at both sites because in Veracruz, people did not accept and use the pyriproxyfen chips.Conclusion Window curtains and domestic water container covers treated with insecticide can reduce densities of dengue vectors to low levels and potentially affect dengue transmission.