Incidence of hypertension by alcohol consumption: is it modified by race?
Incidence of hypertension by alcohol consumption: is it modified by race?
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DOI：
10.1097/01.hjh.0000239282.27938.0f
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发表时间：
2006-08-01
影响因子：
4.9
通讯作者：
Fuchs, Flavio Danni
中科院分区：
文献类型：
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作者：
Steffens, Andre Avelino;Moreira, Leila Beltrami;Fuchs, Flavio Danni
目的探讨种族、酗酒和酒精成瘾对酒精饮料消费与高血压发病关系的影响。方法在一项基于人群的队列研究中，对1089名成年人进行了访谈，并在家中进行了血压和人体测量。他们的饮酒量是通过数量频率问卷来确定的。酗酒被定义为男性一次饮用5杯或以上，女性一次饮用4杯，酗酒被定义为男性每天饮用30克或以上，女性每天饮用15克或以上。高血压病例以血压>= 140/90 mmHg或使用高血压药物为特征。结果在基线随访时589名血压正常的个体中，经过5.6 +/- 1.1年的随访，确定了127例高血压事件。酗酒和酒精依赖与高血压发病率无关。校正后（年龄、教育程度）高血压发病率的风险比（95%置信区间）仅对非白人酒精滥用者有显著性意义：11.8（1.6 -86.9）。黑人施虐者的收缩压升高16.1 +/- 3.5 mmHg，而白人施虐者的收缩压升高4.9 +/- 1.5 mmHg （P = 0.004）。结论：非洲血统的人，摄入大量乙醇，患高血压的风险更高。这种风险不能用酗酒模式或酒精成瘾来解释。
Objective To investigate the influence of race, binge drinking and alcohol addiction on the association between consumption of alcoholic beverages and incidence of hypertension.Methods In a population-based cohort study, 1089 adults were interviewed and had blood pressure and anthropometric measurements carried out at home. Their alcohol consumption was ascertained by an amount frequency questionnaire. Binge drinking was defined as consumption of five or more drinks on one occasion for men or four drinks for women, and abuse of alcohol as consumption of 30 g/day or more in men or 15 g/day or more in women. Incident cases of hypertension were characterized by blood pressure >= 140/90 mmHg or use of hypertension medication.Results Among 589 normotensive individuals in the baseline visit, 127 incident cases of hypertension were identified, after a follow-up of 5.6 +/- 1.1 years. Binge drinking and alcohol dependency were not associated with the incidence of hypertension. Adjusted (age, education) risk ratios for the incidence of hypertension (95% confidence interval) were significant only for non-white abusers of ethanol: 11.8 (1.6 -86.9). Systolic blood pressure of black abusers increased by 16.1 +/- 3.5 mmHg, in comparison with 4.9 +/- 1.5 mmHg among white abusers (P = 0.004).Conclusion Individuals with an African ancestry, who consumed larger amounts of ethanol, are at higher risk of developing hypertension. This risk is not explained by a binge drinking pattern or addiction to alcohol.