PAMAM dendrimer - cell membrane interactions
PAMAM dendrimer - cell membrane interactions
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DOI：
10.1016/j.cis.2018.06.005
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发表时间：
2018-07-01
影响因子：
15.6
通讯作者：
Briscoe, Wuge H.
中科院分区：
文献类型：
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作者：
Fox, Laura J.;Richardson, Robert M.;Briscoe, Wuge H.
PAMAM树枝状大分子由于其可调的物理化学性质而具有广泛的生物医学应用。然而，它们的应用受到其细胞毒性的不确定性的阻碍，这受到树枝状聚合物生成（即大小和表面基团密度），表面化学和剂量以及细胞特异性的影响。本文首先综述了聚酰胺-胺（PAMAM）树枝状大分子的生物医学应用及相关的细胞毒性研究。除了这些体外实验，脂质膜，如支持的脂质双层（SLB），脂质体，和朗缪尔单层已被用作细胞膜模型，研究PAMAM树枝状聚合物膜的相互作用。相关的实验和理论研究进行了总结，并从这些研究的物理见解进行了讨论，揭示了PAMAM树枝状大分子细胞膜相互作用的基本理解。最后，我们总结了一些需要进一步调查的问题。(C)2018作者由爱思唯尔公司出版
PAMAM dendrimers have been conjectured for a wide range of biomedical applications due to their tuneable physicochemical properties. However, their application has been hindered by uncertainties in their cytotoxicity, which is influenced by dendrimer generation (i.e. size and surface group density), surface chemistry, and dosage, as well as cell specificity. In this review, biomedical applications of polyamidoamine (PAMAM) dendrimers and some related cytotoxicity studies are first outlined. Alongside these in vitro experiments, lipid membranes such as supported lipid bilayers (SLBs), liposomes, and Langmuir monolayers have been used as cell membrane models to study PAMAM dendrimer-membrane interactions. Related experimental and theoretical studies are summarized, and the physical insights from these studies are discussed to shed light on the fundamental understanding of PAMAM dendrimer-cell membrane interactions. We conclude with a summary of some questions that call for further investigations. (C) 2018 The Authors. Published by Elsevier B.V.