Autoradiographic localization of dopaminergic and noradrenergic receptors in the bovine pineal gland.
Autoradiographic localization of dopaminergic and noradrenergic receptors in the bovine pineal gland.
复制标题
牛松果体中多巴胺能和去甲肾上腺素能受体的放射自显影定位。
DOI：
10.1111/j.1471-4159.1991.tb06383.x
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发表时间：
1991
影响因子：
4.7
通讯作者：
Murrin,LC
中科院分区：
文献类型：
--
作者：
Simonneaux,V;Happe,HK;Ebadi,M;Murrin,LC
: Dopamine and norepinephrine are involved in regulation of melatonin synthesis in the pineal gland. In bovine pineal gland, D1‐and D2‐dopaminergic and α1‐adrenergic receptors have been characterized pharmacologically in several laboratories, while β1‐adrenergic receptors have been studied using physiological techniques. The current study presents a quantitative autoradiographic analysis of these four dopaminergic and noradrenergic receptors in bovine pineal gland. The density order of the receptors is D1> α1> D2β1.TheBmaxof dopamine D1receptors is about 5 to 6 times higher than theBmaxfor α1adrcnergic receptors and about 20 times higher than theBmaxvalues for β1adrenergic and D2‐dopaminergic receptors. Dopamine D1receptors are significantly denser in the pineal cortex than in the medulla. Both dopamine receptors are more concentrated in the distal area than in the proximal area (close to the habenula), whereas both noradrenergic receptors are homogeneously distributed along the longitudinal axis. Only D1‐dopaminergic receptors display a heterogeneous distribution between the superior and the inferior areas, being denser in the inferior area. The observation of a much higher concentration of D1‐dopaminergic receptors relative to the other receptors suggests an important role for dopamine in the regulation of bovine pineal physiology.
