Non-computer-assisted liquid-based cytology for diagnosis of oral squamous cell carcinoma
Non-computer-assisted liquid-based cytology for diagnosis of oral squamous cell carcinoma
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DOI：
10.3109/10520295.2011.575797
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发表时间：
2012-01-01
影响因子：
1.6
通讯作者：
Garcia-Garcia, A.
中科院分区：
文献类型：
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作者：
Perez-Sayans, M.;Reboiras-Lopez, M. D.;Garcia-Garcia, A.
口腔鳞状细胞癌（OSCC）的发展有时会伴随其他癌前病变的肿瘤进展。虽然活检是确定的诊断方法，但液体细胞学是筛查可疑病变的适当方法。我们比较了液体细胞学和组织学对口腔病变患者OSCC的诊断，这些口腔病变引起了临床对恶性肿瘤的怀疑。我们的样本包括48名患者。使用Cytobrush (R)对病变进行表面刮拭，获得细胞学样本。我们对所有制剂进行细胞学和组织病理学评估。我们估计敏感性和特异性水平以及阳性和阴性预测值。使用kappa指数评估两种方法的观察者间一致性程度。其中28例（58.3%）最终确诊为OSCC， 20例（41.7%）确诊为癌前病变。我们观察到8个假阴性，没有假阳性；OSCC患病率为56.5%。诊断指标值为：敏感性69% (CI 95%，患病率51.87)；特异性,100%;阳性预测值100%；阴性预测值为71% （CI 95% 54.82）。kappa指数为0.622 （CI 95% 0.93, 0.39）。
The development of oral squamous cell carcinoma (OSCC) occasionally follows the neoplastic progression of other premalignant lesions. Although biopsy is the definitive diagnostic method, liquid-based cytology is an adequate method for screening suspicious lesions. We compared liquid-based cytology to histology for diagnosis of OSCC in patients with oral lesions that raised clinical suspicion of malignancy. Our sample consisted of 48 patients. Cytological samples were obtained by scraping the lesion superficially using Cytobrush (R). We conducted cytological and histopathological evaluation of all preparations. We estimated sensitivity and specificity levels as well as positive and negative predictive values. The degree of inter-observer agreement for both methods was assessed using the kappa index. Twenty-eight (58.3%) of the cases finally were diagnosed with OSCC and 20 (41.7%) were determined to be premalignant lesions. We observed eight false negatives and no false positives; OSCC prevalence was 56.5%. The values for diagnostic indices were: sensitivity, 69% (CI 95%, prevalence 51.87); specificity, 100%; positive predictive value, 100%; negative predictive value, 71% (CI 95% 54.82). A kappa index of 0.622 (CI 95% 0.93, 0.39) was observed.