Effects of progesterone and estrogen on the fate of blastocysts in ovariectomized pregnant ferrets: a preliminary study.
Effects of progesterone and estrogen on the fate of blastocysts in ovariectomized pregnant ferrets: a preliminary study.
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黄体酮和雌激素对切除卵巢的怀孕雪貂囊胚命运的影响：一项初步研究。
DOI：
10.1093/biolreprod/7.2.231
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发表时间：
1972
影响因子：
3.6
通讯作者：
M. Chang
中科院分区：
文献类型：
--
作者：
J. Wu;M. Chang
雪貂在妊娠第11天（第0天=交配）出现子宫内膜，第12天着床。在第6天切除卵巢且未接受激素治疗的动物中，未发生着床，到第17天囊胚塌陷或退化，到第21天几乎完全消失。孕激素或孕激素和雌激素的治疗是有益的胚泡的生存，但是，早期植入，如尼亚加拉天蓝色反应和子宫肿胀，一贯延迟1周或更长时间超过正常时间。此外，在第23-28天的子宫内膜中没有胚胎，表明胚泡在着床后不久就退化了。在切除卵巢的雪貂中，孕酮和雌激素的几种方案都未能诱导胚胎的正常着床和发育，这表明激素对着床的控制在这个物种中是非常微妙和精确的。
In ferrets uterine swellings appeared on Day 11 of pregnancy (Day 0 = mating) and implantation occurred on Day 12.In animals ovariectomized on Day 6 and receiving no hormonal treatment, implantation did not take place and the blastocysts were either collapsed or degenerated by Day 17 and had almost completely disappeared by Day 21. Treatments with progesterone or progesterone and estrogen were beneficial to the survival of blastocysts; however, incipient implantation, as indicated by the Niagara Sky Blue reaction and uterine swelling, was consistently delayed for 1 week or longer beyond the normal time. Furthermore, no embryos were present in the uterine swellings on Days 23-28, suggesting that the blastocysts degenerated soon after implantation had been initiated.The failure of several regimens of progesterone and estrogen to induce normal implantation and development of embryos in the ovariectomized ferret suggests that hormonal control of implantation is very delicate and exact in this species.