Multidisciplinary Treatment for Individuals at Clinical High Risk of Developing Psychosis.
Multidisciplinary Treatment for Individuals at Clinical High Risk of Developing Psychosis.
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DOI：
10.1007/s40501-019-0164-6
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发表时间：
2019-03-01
影响因子：
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通讯作者：
Santesteban-Echarri, Olga
中科院分区：
文献类型：
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作者：
Addington, Jean;Devoe, Daniel J;Santesteban-Echarri, Olga
目得：根据临床症状确定有患精神病风险的青年的目标之一是找到预防或甚至延迟疾病发作的方法。在过去的20年里，相对较少的随机对照试验（RCT），包括药理学和心理社会干预，已进行，往往与不一致的结果。最近的几项荟萃分析表明，可能有效的治疗方法很少，而且没有一种治疗方法被认为比任何其他治疗方法更有效。本综述旨在研究现有的随机对照试验，并严格审查最近的荟萃分析。最近的发现：精神病的临床高危个体是一个异质性组。不幸的是，许多干预措施并没有专门设计来解决正在评估的结果，也没有参与者被专门选择为该treatment.Summary：迄今为止完成的试验和最近的系统评价应被积极看待，并用于指导未来试验的设计，以确保在正确的时间向正确的人提供正确的干预措施。
PURPOSE: One of the goals of identifying youth identified, based on clinical symptoms, as being at risk for developing psychosis, is to find ways to prevent or even delay the onset of the illness. Over the past 20 years, relatively few randomized control trials (RCTs), including both pharmacological and psychosocial interventions, have been conducted and often with inconsistent results. Several recent meta-analyses suggest that there are few treatments if any that might be effective and that no one treatment is seen as being more effective than any other treatment. This review aims to examine the existing RCTs and to critically review recent meta-analyses.RECENT FINDINGS: Individuals at clinical high risk for psychosis are a heterogenous group. Unfortunately, many interventions have not been specifically designed to address the outcome being assessed nor have participants been specifically selected for that treatment.SUMMARY: The trials completed to date and the recent systematic reviews should be seen positively and used to guide the design of future trials to ensure that the right interventions are offered to the right people at the right time.