The immune system and the gut microbiota: friends or foes?
The immune system and the gut microbiota: friends or foes?
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DOI：
10.1038/nri2850
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发表时间：
2010-10-01
影响因子：
100.3
通讯作者：
Gaboriau-Routhiau, Valerie
中科院分区：
文献类型：
--
作者：
Cerf-Bensussan, Nadine;Gaboriau-Routhiau, Valerie
哺乳动物的肠道是一个由数万亿细菌组成的复杂群落的家园，这些细菌与宿主免疫系统进行动态相互作用。确定控制宿主-微生物群关系的原则是密集研究的焦点。在这里，我们描述了肠道微生物群如何能够影响促炎反应和调节反应之间的平衡，并塑造宿主的免疫系统。我们认为，提高我们对肠道微生物群的理解具有治疗意义，不仅对肠道免疫病理学，而且对全身性免疫疾病。
The mammalian intestine is home to a complex community of trillions of bacteria that are engaged in a dynamic interaction with the host immune system. Determining the principles that govern host-microbiota relationships is the focus of intense research. Here, we describe how the intestinal microbiota is able to influence the balance between pro-inflammatory and regulatory responses and shape the host's immune system. We suggest that improving our understanding of the intestinal microbiota has therapeutic implications, not only for intestinal immunopathologies but also for systemic immune diseases.