Associations between APOE polymorphisms and seven diseases with cognitive impairment including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies in southeast China.
Associations between APOE polymorphisms and seven diseases with cognitive impairment including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies in southeast China.
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APOE多态性与中国东南地区阿尔茨海默病、额颞叶痴呆、路易体痴呆等七种认知障碍疾病的相关性
DOI：
10.1097/ypg.0000000000000126
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发表时间：
2016-06
影响因子：
0.9
通讯作者：
Guo QH
中科院分区：
文献类型：
--
作者：
Chen KL;Sun YM;Zhou Y;Zhao QH;Ding D;Guo QH
补充数字内容可在文本中找到。探讨APOE多态性对中国汉族认知障碍患者的影响。本研究于2010年1月至2014年12月在华山医院记忆障碍门诊连续招募阿尔茨海默病（AD） 1027例、血管性痴呆（VaD） 40例、行为变异性额颞叶痴呆（bvFTD） 28例、语义性痴呆（SD） 54例、路易体痴呆（DLB） 44例、轻度认知障碍（MCI） 583例、血管性认知障碍无痴呆（VCIND） 32例。从社区流行病学调查中招募认知正常对照1149人。采用TaqMan法测定APOE基因型。APOE基因型和等位基因频率分布在对照组与AD和MCI之间存在显著差异，ε4呈剂量依赖性增加AD和MCI的风险，而ε2降低AD的风险，但对MCI的风险没有影响。对于VaD， APOE基因型分布与对照组相比有显著差异。E4/4增加VaD的风险，ε4增加vind的风险。bvFTD的等位基因分布与对照组不同，但APOE的基因型和等位基因频率对bvFTD、SD和DLB的风险没有影响。在中国汉族人群中，APOE ε4以剂量依赖的方式增加AD和MCI的风险，而ε2则降低AD的风险。APOE ε4可能增加VaD和女性vind患者的风险，但APOE对bvFTD、DLB和SD无影响。
Supplemental Digital Content is available in the text. To explore the effect of APOE polymorphisms on patients with cognitive impairments in The Chinese Han population. A total of 1027 cases with Alzheimer’s disease (AD), 40 cases with vascular dementia (VaD), 28 cases with behavioral variant frontotemporal dementia (bvFTD), 54 cases with semantic dementia (SD), 44 cases with dementia with Lewy bodies (DLB), 583 cases with mild cognitive impairment (MCI), and 32 cases with vascular cognitive impairment no dementia (VCIND) were recruited consecutively from memory disorders clinics in Huashan Hospital between January 2010 and December 2014. The 1149 cognitively normal controls were recruited from the community epidemiologic investigations. The APOE genotypes were determined using the TaqMan assay. The distribution of genotype and allele frequencies of APOE differed significantly between control and AD or MCI, with ε4 increasing the risk of AD and MCI in a dose-dependent pattern and ε2 decreasing the risk of AD, but not the risk of MCI. As for VaD, significant differences in the APOE genotype distribution were found compared with the controls. E4/4 increased the risk of VaD and ε4 increased the risk of VCIND in women. The allele distribution differed between bvFTD and controls, but genotype and allele frequencies of APOE did not affect the risk of bvFTD, SD, and DLB. In The Chinese Han population, APOE ε4 increased the risk of AD and MCI in a dose-dependent manner and ε2 decreased the risk of AD as reported previously. APOE ε4 might increase risk in VaD and female patients with VCIND, but no effects of APOE on bvFTD, DLB, and SD were found.