Asymptomatic Carriers of Plasmodium spp. as Infection Source for Malaria Vector Mosquitoes in the Brazilian Amazon
Asymptomatic Carriers of Plasmodium spp. as Infection Source for Malaria Vector Mosquitoes in the Brazilian Amazon
复制标题
疟原虫属无症状携带者。
DOI：
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发表时间：
2005
影响因子：
2.1
通讯作者：
L. H. Pereira da Silva
中科院分区：
文献类型：
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作者：
F. Alves;L. H. S. Gil;M. T. Marrelli;P. Ribolla;E. P. Camargo;L. H. Pereira da Silva
摘要我们已经描述了亚马逊土著人群中存在间日疟原虫和恶性疟原虫感染的无症状携带者。大多数患者的寄生虫血症较低，仅通过聚合酶链反应（PCR）检测。因为它们仍然没有被感染和治疗，我们想确定它们是否可以感染巴西主要的媒介--达林基按蚊根，并作为疾病的储存库。选择15名成年无症状患者（仅PCR阳性），并通过直接喂食和膜喂食系统进行蚊子的实验感染。17例有高寄生虫血症的成人症状患者作为对照。我们发现安的感染率。darlingi无症状携带者为1.2%，有症状携带者为22%。尽管无症状组感染蚊子的速度要低得多，但这些患者比接受治疗的有症状患者保持感染的时间更长。此外，无症状感染者的患病率是当地人中有症状感染者的4至5倍。这些结果对巴西的疟疾控制计划有影响，该计划主要关注症状患者的治疗。
Abstract We have described the existence of asymptomatic carriers of Plasmodium vivax and Plasmodium falciparum infections in native Amazon populations. Most of them had low parasitemias, detected only by polymerase chain reaction (PCR). Because they remain symptomless and untreated, we wanted to determine whether they could infect Anopheles darlingi Root, the main Brazilian vector, and act as disease reservoirs. Fifteen adult asymptomatic patients (PCR positive only) were selected, and experimental infections of mosquitoes were performed by direct feeding and by a membrane-feeding system. Seventeen adult symptomatic patients with high parasitemias were used as controls. We found an infection rate in An. darlingi of 1.2% for the asymptomatic carriers and 22% for the symptomatic carriers. Although the asymptomatic group infected mosquitoes at a much lower rate, these patients remain infective longer than treated, symptomatic patients. Also, the prevalence of asymptomatic infections is 4 to 5 times higher than symptomatic infections among natives. These results have implications for the malaria control program in Brazil, which focuses essentially on the treatment of symptomatic patients.