TROPHOBLAST DIFFERENTIATION DURING THE TRANSITION FROM TROPHOBLASTIC PLATE TO LACUNAR STAGE OF IMPLANTATION IN THE RHESUS-MONKEY AND HUMAN
TROPHOBLAST DIFFERENTIATION DURING THE TRANSITION FROM TROPHOBLASTIC PLATE TO LACUNAR STAGE OF IMPLANTATION IN THE RHESUS-MONKEY AND HUMAN
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DOI：
10.1002/aja.1001860107
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发表时间：
1989-09-01
影响因子：
--
通讯作者：
ENDERS, AC
中科院分区：
文献类型：
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作者：
ENDERS, AC
从滋养层板阶段的早期腔隙阶段的过渡进行了检查，在一系列的植入位点从恒河猴，定时排卵前雌激素峰值的基础上，并准备透射电子显微镜。将这种转变与卡内基人类胚胎收藏中的5a、B和c阶段的标本进行了比较。这种转变的标志是一种新型合胞体滋养层的分化，即单层微绒毛极化合胞体，它在整个滋养层板中发育，形成特征性的胞内裂。这种类型的合胞体的快速发育为母体血液创造了一个不凝结的腔室，滋养细胞侵入母体血管产生汇合。虽然卡内基系列中的材料的性质排除了滋养层的细胞学表征，但有证据表明，在人类滋养层中发生了类似的转变，并且在人类中，腔隙的出现也标志着从早期侵入性滋养层到生长更显著的情况的变化。
The transition from the trophoblastic plate stage to the early lacunar stage was examined in a series of implantation sites from the rhesus monkey, timed on the basis of the preovulatory estrogen peak, and prepared for transmission electron microscopy. This transition was compared with specimens from stage 5a, b, and c in the Carnegie collection of human embryos. The transition was marked by teh differentiation of a new type of syncytial trophoblast-namely, a unilaminar microvillous polarized syncytium, which developed throughout the trophoblastic plate, forming characteristic intrasyncytial clefts. The rapid development of this type of syncytium created a nonclotting chamber for maternal blood wherever trophoblast intrusion into maternal vessels created confluence. Although the nature of the material in the Carnegie series precluded cytological characterization of the trophoblast, there is evidence that a similar transition occurs in human trophoblast and that in the human also the appearance of lacunae marks a change from an early invasive trophoblast to a situation in which growth is more significant.