A randomized trial of exercise training after renal transplantation
A randomized trial of exercise training after renal transplantation
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DOI：
10.1097/00007890-200207150-00008
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发表时间：
2002-07-15
期刊：
影响因子：
6.2
通讯作者：
Ascher, NL
中科院分区：
文献类型：
--
作者：
Painter, PL;Hector, L;Ascher, NL
背景。定期的体育活动对健康有显著的好处，其中许多对移植受者很重要。虽然运动能力在移植后最初有所改善，但并不是正常化的，只有两项研究报道了运动训练对这一人群的影响。我们报道了一项肾移植后运动的随机临床试验。167例患者在RTX后1个月随机分为两组：运动干预（EX）和常规护理（UC），并在6个月和12个月重复测试。95名患者在两个测试时间完成了以下测试：症状受限的跑步机测试，测量峰值摄氧量（峰值VO2）；肌肉力量等速肌肉测试；双能x光吸收仪扫描人体成分。SF-36健康状况问卷评估自我报告的功能。运动干预包括个人规定的项目，在家中进行，定期电话随访，以提高依从性。进行重复测量方差分析，以确定三个测试时间组间的差异。在第67年，EX组中有0人定期锻炼，而36%的人定期锻炼。（P=0.01）。与UC组相比，EX组在峰值VO2 （P=0.016）、年龄预测VO2百分比（P=0.03）和肌肉力量（P=0.05）方面有显著增加，并且自我报告的身体功能有更高的趋势（P=0.06）。两组之间的身体成分变化没有差异。1年后，VO2峰值与年龄、脂肪百分比、肌肉力量、红细胞压积和自我报告的身体功能显著相关。RTX后的运动训练导致更高水平的测量和自我报告的身体功能；然而，运动本身不会影响身体成分。
Background. Significant health benefits result from regular physical activity, many which are important for transplant recipients. Although exercise capacity improves initially after transplant, it is not normalized, and only two studies have reported the effects of exercise training in this population. We report a randomized clinical trial of exercise after renal transplantation (RTX).Methods. One hundred sixty-seven patients were randomized at 1 month after RTX into two groups: exercise intervention (EX) and usual care (UC), with repeat testing at 6 and 12 months. Ninety-five patients completed the following testing at both testing times: symptom-limited treadmill testing with measurement of peak oxygen uptake (peak VO2); isokinetic muscle testing for muscle strength; and dual-energy X-ray absorptiometry scans for body composition. The SF-36 Health Status Questionnaire assessed self-reported functioning. The exercise intervention consisted of individually prescribed programs to be conducted at home with regular phone follow-up to enhance adherence. Repeated measures analysis of variance was performed to determine differences between the groups for the three testing times.Results. At 1 year 67,0 of the EX group were exercising regularly compared with 36%. of the UC group (P=0.01). Compared with the UC group, the EX group had significantly greater gains in peak VO2 (P=0.016), percent age-predicted VO2 (P=0.03), and muscle strength (P=0.05), and a trend toward higher self-reported physical functioning (P=0.06). There were no differences between the groups in changes in body composition. At 1 year, peak VO2 was significantly correlated with age, percent fat, muscle strength, hematocrit, and self-reported physical functioning.Conclusions. Exercise training after RTX results in higher levels of measured and self-reported physical functioning; however, exercise alone does not affect body composition.