Genetics of the Shimokita macaque population suggest an ancient bottleneck
Genetics of the Shimokita macaque population suggest an ancient bottleneck
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DOI：
10.1007/s10329-007-0057-y
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发表时间：
2008-01-01
期刊：
影响因子：
1.7
通讯作者：
Kawamoto, Sakie
中科院分区：
文献类型：
--
作者：
Kawamoto, Yoshi;Tomari, Ken-ichiro;Kawamoto, Sakie
下基塔半岛的猕猴种群代表了该物种最北端的分布，与日本东北地区的其他种群隔离。先前的一项基于蛋白质的研究显示，该人群的遗传变异性很高，与其他人群有很大的差异。为了重新评估下野猕猴的遗传特征，我们检测了11个常染色体微卫星位点和3个Y染色体微卫星位点。我们观察到与其他日本猕猴种群有相当大的差异，但与之前的结果相反，我们观察到这个种群的遗传变异性明显较低。有一个微弱的种群瓶颈的迹象，表明随着时间的推移，过多的杂合子可能会在瓶颈的初始阶段出现衰减。这可能表明，古代的瓶颈发生在末次冰期后的温暖期，而不是近代由于狩猎造成的最近的瓶颈。在Shimokita人群中，私有等位基因的频率异常高，这表明在各种研究中确定的变异性差异是由于偶然取样的标记位点在蛋白质基础研究中具有较低的解决遗传变异的能力。使用常染色体和Y染色体标记确定的种群间分化评估是高度相关的，并且使用两种类型的标记发现Shimokita群体是研究群体中分化程度最高的，可能是由于与周围群体的基因流动不频繁。
The macaque population of the Shimokita Peninsula represents the northernmost distribution of this species and is isolated from other populations in the Tohoku region of Japan. A previous protein-based study revealed a high level of genetic variability in this population and considerable differentiation from other populations. In order to reassess the genetic features of the Shimokita macaques, we examined 11 autosomal microsatellite loci and three Y chromosomal microsatellite loci. We observed considerable differentiation from other Japanese populations of macaques, but in contrast to the previous results, we observed significantly lower genetic variability in this population. There was a weak indication of a population bottleneck, suggesting a decay over time from an excess of heterozygotes that might be expected in the initial stages of a bottleneck. This may indicate that an ancient bottleneck occurred during the warm period after the last glacial period rather than a recent bottleneck due to hunting in modern times. The frequencies of private alleles were exceptionally high in the Shimokita population, suggesting that the difference in variability as determined in various studies was due to accidental sampling of marker loci with low power to resolve genetic variations in the protein-based studies. The assessments of interpopulation differentiation as determined using autosomal and Y chromosomal markers were highly correlated, and using both types of markers the Shimokita population was found to be the most differentiated of the study populations, probably due to infrequent gene flow with surrounding populations.