Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases.
Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases.
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DOI：
10.1155/2016/9392132
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发表时间：
2016
影响因子：
4.1
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Shi J;Chi S;Xue J;Yang J;Li F;Liu X
Wnt信号通路在许多生物学方面起着关键作用，如细胞增殖、组织再生、胚胎发育和其他全身效应。在生理条件下，它在不同的层和阵列中受到严格控制，并且这种信号传导的失调激活已经涉及各种人类疾病（包括自身免疫性疾病）的发病机制。尽管治疗性干预可用于改善疾病表现，但目前还没有可用于自身免疫性疾病的治愈性疗法。越来越多的证据表明Wnt信号在许多自身免疫性疾病的发病机制中起着至关重要的作用;此外，一些microRNA（miRNAs），一类能够转录调节基因表达的小的非编码RNA分子，最近也被证明通过调节Wnt信号通路在自身免疫性疾病中具有生理和病理作用。本文综述了Wnt信号通路在几种主要自身免疫性疾病中的致病作用，以及Wnt信号通路在自身免疫性疾病中的靶向miRNA，重点介绍了Wnt信号通路作为免疫性疾病的潜在生物标志物和治疗靶点的意义，以及miRNA介导的Wnt信号通路激活在自身免疫性疾病发展中的调控作用。
The Wnt signaling pathway plays a key role in many biological aspects, such as cellular proliferation, tissue regeneration, embryonic development, and other systemic effects. Under a physiological condition, it is tightly controlled at different layers and arrays, and a dysregulated activation of this signaling has been implicated into the pathogenesis of various human disorders, including autoimmune diseases. Despite the fact that therapeutic interventions are available for ameliorating disease manifestations, there is no curative therapy currently available for autoimmune disorders. Increasing lines of evidence have suggested a crucial role of Wnt signaling during the pathogenesis of many autoimmune diseases; in addition, some of microRNAs (miRNAs), a class of small, noncoding RNA molecules capable of transcriptionally regulating gene expression, have also recently been demonstrated to possess both physiological and pathological roles in autoimmune diseases by regulating the Wnt signaling pathway. This review summarizes currently our understanding of the pathogenic roles of Wnt signaling in several major autoimmune disorders and miRNAs, those targeting Wnt signaling in autoimmune diseases, with a focus on the implication of the Wnt signaling as potential biomarkers and therapeutic targets in immune diseases, as well as miRNA-mediated regulation of Wnt signaling activation in the development of autoimmune diseases.