Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes: The PREDO Study.
Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes: The PREDO Study.
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DOI：
10.1371/journal.pone.0150058
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Räikkönen K
中科院分区：
文献类型：
--
作者：
Pesonen AK;Lahti M;Kuusinen T;Tuovinen S;Villa P;Hämäläinen E;Laivuori H;Kajantie E;Räikkönen K
我们在大型PREDO研究中调查了母亲产前情绪是否与妊娠期长度和出生体重相关，该研究在妊娠期间进行了多个情绪测量点。对3376名孕妇在妊娠期间进行了14次积极情感（PA，积极和消极情感量表）、抑郁（流行病学研究中心抑郁量表，CES-D）和焦虑（Spielberger状态焦虑量表，STAI）症状自评。出生特征来自国家出生登记册和医疗记录。妊娠晚期PA高1个标准差（SD）单位与妊娠期长0.05个SD单位相关，而妊娠晚期CES-D和STAI评分高1个SD单位与妊娠期短0.04-0.05个SD单位相关（P值≤ 0.02），仅对应于妊娠期长变化的0.1-0.2%。妊娠晚期较高的PA与早产（< 37周）的风险显著降低相关（对于每个SD单位较高的积极影响，比值比为0.8倍（P = 0.02））。早产的母亲在分娩前8周内PA下降，CES-D和STAI增加。过期分娩（≥ 42周）、出生体重和胎儿生长与母亲产前情绪无关。这项研究与14个测量母亲的情绪在怀孕期间显示适度的影响产前情绪在怀孕的第三个三个月，特别是在几周接近分娩，妊娠期的长度。从临床角度来看，影响可以忽略不计。产前情绪和出生体重之间没有关联。
We investigated whether maternal prenatal emotions are associated with gestational length and birth weight in the large PREDO Study with multiple measurement points of emotions during gestation. Altogether 3376 pregnant women self-assessed their positive affect (PA, Positive and Negative Affect Schedule) and depressive (Center for Epidemiologic Studies Depression Scale, CES-D) and anxiety (Spielberger State Anxiety Scale, STAI) symptoms up to 14 times during gestation. Birth characteristics were derived from the National Birth Register and from medical records. One standard deviation (SD) unit higher PA during the third pregnancy trimester was associated with a 0.05 SD unit longer gestational length, whereas one SD unit higher CES-D and STAI scores during the third trimester were associated with 0.04–0.05 SD unit shorter gestational lengths (P-values ≤ 0.02), corresponding to only 0.1–0.2% of the variation in gestational length. Higher PA during the third trimester was associated with a significantly decreased risk for preterm (< 37 weeks) delivery (for each SD unit higher positive affect, odds ratio was 0.8-fold (P = 0.02). Mothers with preterm delivery showed a decline in PA and an increase in CES-D and STAI during eight weeks prior to delivery. Post-term birth (≥ 42 weeks), birth weight and fetal growth were not associated with maternal prenatal emotions. This study with 14 measurements of maternal emotions during pregnancy show modest effects of prenatal emotions during the third pregnancy trimester, particularly in the weeks close to delivery, on gestational length. From the clinical perspective, the effects were negligible. No associations were detected between prenatal emotions and birth weight.