Bilayer Hydrogels by Reactive-Induced Macrophase Separation
Bilayer Hydrogels by Reactive-Induced Macrophase Separation
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DOI：
10.1021/acsmacrolett.3c00149
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发表时间：
2023-04-17
影响因子：
7.015
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
--
作者：
Zhang, Dong;Tang, Yijing;Zheng, Jie
具有智能功能的双层水凝胶因其在机械和化学性质设计方面的通用性和灵活性而成为生物组织工程和人机界面的一种很有前途的软材料。然而，传统的制备方法通常需要多个复杂的步骤来创建界面较差的各向异性双层结构，这大大限制了双层水凝胶的应用范围。在这里，我们报道了一种通用的一锅大相分离策略，以制备一系列由乙烯基和苯乙烯单体制成的双层水凝胶，具有无缝的界面和可控的层分离效率(20%-99%)。大相分离策略的工作原理允许通过操纵乙烯基单体和苯乙烯基单体之间的竞争聚合反应，使两个凝胶过程解耦，形成不同的富含乙烯基和苯乙烯基的层。这项工作提供了一种简单的方法和一系列不同的自由基单体，可以用来创造新一代双层水凝胶，而不是目前可用的几种。
Bilayer hydrogels encoded with smart functions have emerged as promising soft materials for engineered biological tissues and human-machine interfaces, due to the versatility and flexibility in designing their mechanical and chemical properties. However, conventional fabrication strategies often require multiple complicated steps to create an anisotropic bilayer structure with poor interfaces, which significantly limit the scope of bilayer hydrogel applications. Here, we reported a general, one-pot, macrophase separation strategy to fabricate a family of bilayer hydrogels made of vinyl and styryl monomers with a seamless interface and a controllable layer separation efficiency (20-99%). The working principle of a macrophase separation strategy allows for the decoupling of the two gelation processes to form distinct vinyl- and styryl-enriched layers by manipulating competitive polymerization reactions between vinyl and styryl monomers. This work presents a straightforward approach and a diverse range of radical monomers, which can be utilized to create next-generation bilayer hydrogels, beyond a few available today.