Influence of breast-feeding and oral poliovirus vaccine on the immunogenicity and efficacy of rotavirus vaccines
Influence of breast-feeding and oral poliovirus vaccine on the immunogenicity and efficacy of rotavirus vaccines
复制标题
DOI：
10.1093/infdis/174.supplement_1.s107
复制
发表时间：
1996-09-01
影响因子：
6.4
通讯作者：
Rennels, MB
中科院分区：
文献类型：
--
作者：
Rennels, MB
为了实用和成本效益，轮状病毒疫苗必须与常规儿童疫苗接种一起给予婴儿。综述了轮状病毒疫苗研究，以评价母乳喂养和同时口服脊髓灰质炎疫苗（OPV）对口服轮状病毒疫苗免疫原性和有效性的影响。母乳喂养和口服脊髓灰质炎疫苗似乎都在一定程度上干扰了轮状病毒疫苗的血清免疫应答;然而，这些影响通常没有统计学意义，并且在很大程度上可以通过接种三剂轮状病毒疫苗而不是一剂来克服。现有数据显示，在母乳喂养的儿童或同时接受口服脊髓灰质炎疫苗的儿童中，轮状病毒疫苗的保护效力没有下降，但需要更大的样本量才能明确排除任何影响。
To be practical and cost effective, rotavirus vaccines will have to be administered to infants with routine childhood vaccinations. Rotavirus vaccine studies were reviewed to evaluate the effect of breast-feeding and concurrent oral poliovirus vaccination (OPV) on the immunogenicity and efficacy of oral rotavirus vaccines. Both breast-feeding and OPV appeared to interfere, to some degree, with the serum immune response to rotavirus vaccines; however, the effects were usually not statistically significant and were largely overcome by administering three doses of rotavirus vaccine rather than one. Available data show no decrease in the protective efficacy of rotavirus vaccine in breast-fed children or in children receiving concurrent OPV, but larger sample sizes will be required to definitely rule out any effect.