Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis?
Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis?
复制标题
调节性 T 细胞：脓毒症病理生理学中的天使还是恶魔？
DOI：
10.3389/fimmu.2022.829210
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发表时间：
2022
影响因子：
7.3
通讯作者：
Chai YF
中科院分区：
文献类型：
--
作者：
Gao YL;Yao Y;Zhang X;Chen F;Meng XL;Chen XS;Wang CL;Liu YC;Tian X;Shou ST;Chai YF
Sepsis is a syndrome characterized by life-threatening organ dysfunction caused by the dysregulated host response to an infection. Sepsis, especially septic shock and multiple organ dysfunction is a medical emergency associated with high morbidity, high mortality, and prolonged after-effects. Over the past 20 years, regulatory T cells (Tregs) have been a key topic of focus in all stages of sepsis research. Tregs play a controversial role in sepsis based on their heterogeneous characteristics, complex organ/tissue-specific patterns in the host, the multi-dimensional heterogeneous syndrome of sepsis, the different types of pathogenic microbiology, and even different types of laboratory research models and clinical research methods. In the context of sepsis, Tregs may be considered both angels and demons. We propose that the symptoms and signs of sepsis can be attenuated by regulating Tregs. This review summarizes the controversial roles and Treg checkpoints in sepsis.
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DOI：
10.4049/jimmunol.1700375
发表时间：
2017-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chen CW;Mittal R;Klingensmith NJ;Burd EM;Terhorst C;Martin GS;Coopersmith CM;Ford ML
通讯作者：
Ford ML
影响因子：
5.5
作者：
Albayati, Samara;Vemulapalli, Harika;Liverani, Elisabetta
通讯作者：
Liverani, Elisabetta
DOI：
10.1186/cc12711
发表时间：
2013-05-11
期刊：
Critical care (London, England)
影响因子：
--
作者：
Chang KC;Burnham CA;Compton SM;Rasche DP;Mazuski RJ;McDonough JS;Unsinger J;Korman AJ;Green JM;Hotchkiss RS
通讯作者：
Hotchkiss RS
影响因子：
15.9
作者：
Chen, Guang;Wu, Di;Ning, Qin
通讯作者：
Ning, Qin
影响因子：
3.6
作者：
Ahmadi, N.;Ahmadi, A.;Mahdavi, M.
通讯作者：
Mahdavi, M.