DETERMINING A MINIMAL IMPORTANT CHANGE IN A DISEASE-SPECIFIC QUALITY-OF-LIFE QUESTIONNAIRE
DETERMINING A MINIMAL IMPORTANT CHANGE IN A DISEASE-SPECIFIC QUALITY-OF-LIFE QUESTIONNAIRE
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DOI：
10.1016/0895-4356(94)90036-1
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发表时间：
1994-01-01
影响因子：
7.2
通讯作者：
GRIFFITH, LE
中科院分区：
文献类型：
--
作者：
JUNIPER, EF;GUYATT, GH;GRIFFITH, LE
本研究旨在确定使用7分量表的生活质量评价工具的最小重要差异在各个领域以及改善和恶化方面是否相似。研究了39名成人哮喘患者，使用8周队列，在0、4和g周进行评估。结果是哮喘生活质量问卷和全球变化评级。对于总体哮喘特异性生活质量和所有个体领域（活动、情绪、症状），每项生活质量评分的最小重要差异非常接近0.5（范围：0.42-0.58）;差异约1.0表示中度变化（范围：0.77-1.51）;差异大于1.5表示较大变化。改善和恶化的变化非常相似。代表最小重要差异的生活质量评分变化与其他评价工具观察到的变化非常相似。观察到最小重要差异在各个领域以及改善和恶化方面是一致的，这将有助于解释检查生活质量的研究结果。
This study was carried out to determine whether the minimal important difference, in evaluative quality of life instruments which use a 7-point scale, is similar across individual domains and for both improvement and deterioration. Thirty nine adults with asthma were studied, using an 8 week cohort with assessments at 0, 4 and g weeks. The outcomes were the Asthma Quality of Life Questionnaire and global rating of change. For overall asthma-specific quality of life and for all individual domains (activities, emotions, symptoms), the minimal important difference of quality of life score per item was very close to 0.5 (range: 0.42-0.58); differences of approximately 1.0 represented a moderate change (range: 0.77-1.51); differences greater than 1.5 represented large changes. Changes for improvement and deterioration were very similar. The changes in quality of life score that represent a minimal important difference are very similar to those observed for other evaluative instruments. The observation that the minimal important difference is consistent across domains and for both improvement and deterioration will facilitate interpretation of results of studies examining quality of life.