Iron-Catalyzed Direct Arylationof Aryl Pyridines and Imines Using Oxygen as an Oxidant
Iron-Catalyzed Direct Arylationof Aryl Pyridines and Imines Using Oxygen as an Oxidant
复制标题
使用氧气作为氧化剂铁催化芳基吡啶和亚胺的直接芳基化
DOI：
10.1055/s-0029-1219184
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发表时间：
2010
期刊：
影响因子：
2
通讯作者：
E. Nakamura
中科院分区：
文献类型：
--
作者：
N. Yoshikai;A. Matsumoto;Jakob Norinder;E. Nakamura
铁催化的芳基吡啶或亚胺与芳基锌试剂的邻位C-H键芳基化反应，以前需要使用相当昂贵的有机二氯乙烷作为氧化剂，现在可以在氧气气氛下实现。通过向反应中缓慢引入氧气，两种反应物的氧化交叉偶联平稳地发生，以中等至良好的产率得到联芳基产物。
An iron-catalyzed ortho C―H bond arylation reaction of an aryl pyridine or imine with an arylzinc reagent, which previously required the use of a rather expensive organodichloride as an oxidant, can now be achieved under oxygen atmosphere. By slowly introducing oxygen into the reaction, oxidative cross-coupling of the two reactants took place smoothly to give a biaryl product in moderate to good yield.