Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.
Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.
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Spingofungins G 和 H：来自青霉曲霉 Speg 的新五元内酯。
DOI：
10.1080/14786419.2018.1470627
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发表时间：
2019-05-03
影响因子：
2.2
通讯作者：
Zhang, Ying-Jun
中科院分区：
文献类型：
--
作者：
Zhang, Han;Zhu, Hong-Tao;Zhang, Ying-Jun
摘要从青霉曲霉固态发酵产物中鉴定出两个新的五元内酯环鞘氨醇类化合物G（1）和H（2），一个优势微生物分离先前从后发酵成熟普洱茶，连同六个已知的代谢产物。通过多种光谱方法鉴定了它们的结构。它们都是从A.青霉菌属首次。已知化合物锥虫肽对五种人类癌细胞系（例如髓性白血病HL-60、肺癌A-549、肝细胞癌SMMC 7721、乳腺癌MCF-7和结肠癌SW 480）表现出有效的细胞毒性，IC 50值分别为0.55、11.45、10.95、3.58和3.49 μM，顺铂为阳性对照，IC_（50）分别为8.63、24.15、21.99、27.29和23.61 μM。
Abstract Two new sphingofungins G (1) and H (2) with a five-membered lactone ring were identified from the solid-state fermentation of Aspergillus penicilliodes Speg., a dominant microorganism isolated previously from the post-fermentation of ripe Pu-er tea, together with six known metabolites. Their structures were elucidated by extensive spectroscopic methods. All of them were isolated from the mycelia culture of A. penicilliodes for the first time. The known compound, trypacidin, exhibited potent cytotoxities against five human cancer cell lines, e.g. myeloid leukemia HL-60, lung cancer A-549, hepatocellular carcinoma SMMC7721, breast cancer MCF-7, and colon cancer SW480, with IC50 values of 0.55, 11.45, 10.95, 3.58, and 3.49 μM, resp., while cisplatin as the positive control, with IC50 values of 8.63, 24.15, 21.99, 27.29, and 23.61 μM, resp.