Preeclampsia: At risk for remote cardiovascular disease
Preeclampsia: At risk for remote cardiovascular disease
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DOI：
10.1097/maj.0b013e3180a6f094
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发表时间：
2007-10-01
影响因子：
3.1
通讯作者：
Zeeman, Gerda G.
中科院分区：
文献类型：
--
作者：
Harskamp, Ralf E.;Zeeman, Gerda G.
流行病学数据表明，患有先兆子痫的女性在以后的生活中更有可能患上心血管疾病（CVD）。基于人群的研究表明，与血压正常的妊娠相比，先兆子痫与后期慢性高血压（RR，2.00 至 8.00）和心血管发病/死亡率（RR，1.3 至 3.07）的风险增加有关。妊娠 36 周前发生先兆子痫或妊娠多次高血压的女性风险最高（RR，3.4 至 8.12）。先兆子痫远程影响的潜在机制很复杂，而且可能是多因素的。 CVD和先兆子痫有许多共同的危险因素，包括内皮功能障碍、肥胖、高血压、高血糖、胰岛素抵抗和血脂异常。因此，有人提出代谢综合征可能是CVD和先兆子痫共同的潜在机制。对有先兆子痫病史的女性进行随访和咨询可能会为预防未来疾病提供机会。
Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to 3.07), compared with normotensive pregnancy. Women who develop preeclampsia before 36 weeks of gestation or have multiple hypertensive pregnancies are at highest risk (RR, 3.4 to 8.12). The underlying mechanism for the remote effects of preeclampsia is complex and probably multifactorial. Many risk factors are shared by CVD and preeclampsia, including endothelial dysfunction, obesity, hypertension, hyperglycemia, insulin resistance, and dyslipidemia. Therefore, it has been proposed that the metabolic syndrome may be a possible underlying mechanism common to CVD and preeclampsia. Follow-up and counseling of women with a history of preeclampsia may offer a window of opportunity for prevention of future disease.