Mixed Dyslipidemia, Metabolic Syndrome, Diabetes Mellitus, and Cardiovascular Disease: Clinical Implications
Mixed Dyslipidemia, Metabolic Syndrome, Diabetes Mellitus, and Cardiovascular Disease: Clinical Implications
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DOI：
10.1016/j.amjcard.2008.09.067
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发表时间：
2008-12-22
影响因子：
2.8
通讯作者：
Cannon, Christopher P.
中科院分区：
文献类型：
--
作者：
Cannon, Christopher P.
代谢综合征和2型糖尿病单独与心血管风险增加相关;此外，代谢综合征与糖尿病的组合加重了这种风险。以甘油三酯升高、高密度脂蛋白胆固醇降低或这两种情况为特征的致动脉粥样硬化性血脂异常是与这两种情况相关的关键可改变风险因素。由于这种致动脉粥样硬化的混合性血脂异常的发展先于显性糖尿病的发作和糖尿病的临床诊断，因此建议早期有效干预以降低过早心血管疾病发病率和死亡率的风险。(c)2008年爱思唯尔公司All rights reserved. (Am J Cardiol 2008;102[增刊]：5L-9 L）
Metabolic syndrome and type 2 diabetes mellitus are individually associated with increased cardiovascular risk; furthermore, the combination of metabolic syndrome with diabetes accentuates this risk. An atherogenic dyslipidemia characterized by elevated triglycerides, low high-density lipoprotein cholesterol, or both conditions is a key modifiable risk factor associated with both conditions. As the development of this atherogenic mixed dyslipidemia precedes the onset of overt glycemia and the clinical diagnosis of diabetes, early effective intervention is recommended to reduce the risk of premature cardiovascular disease morbidity and mortality. (c) 2008 Elsevier Inc. All rights reserved. (Am J Cardiol 2008;102[suppl]:5L-9L)