AtCCS is a functional homolog of the yeast copper chaperone Ccs1/Lys7
AtCCS is a functional homolog of the yeast copper chaperone Ccs1/Lys7
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DOI：
10.1016/j.febslet.2005.03.025
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发表时间：
2005-04-25
期刊：
影响因子：
3.5
通讯作者：
Pilon, M
中科院分区：
文献类型：
--
作者：
Abdel-Ghany, SE;Burkhead, JL;Pilon, M
在植物叶绿体中，存在两种超氧化物歧化酶 (SOD) 活性：FeSOD 和 Cu/ZnSOD，并根据铜的可用性进行相互调节。该系统提供了一个独特的模型来研究金属辅因子传递到细胞器的调节。拟南芥基因 AtCCS 编码酵母 Ccs1p/Lys7p 的功能同源物，Ccs1p/Lys7p 是 SOD 的铜伴侣。 AtCCS 蛋白定位于叶绿体，在那里它可以向基质 Cu/ZnSOD 提供铜。 AtCCS mRNA 表达水平响应铜喂养和衰老而上调。我们建议调节 AtCCS 表达，以允许最优化地利用 Cu 进行光合作用。 (c) 2005 年欧洲生化学会联合会。由 Elsevier B.V. 出版。保留所有权利。
In plant chloroplasts two superoxide dismutase (SOD) activities occur, FeSOD and Cu/ZnSOD, with reciprocal regulation in response to copper availability. This system presents a unique model to study the regulation of metal-cofactor delivery to an organelle. The Arabidopsis thaliana gene AtCCS encodes a functional homolog to yeast Ccs1p/Lys7p, a copper chaperone for SOD. The AtCCS protein was localized to chloroplasts where it may supply copper to the stromal Cu/ZnSOD. AtCCS mRNA expression levels are upregulated in response to Cu-feeding and senescence. We propose that AtCCS expression is regulated to allow the most optimal use of Cu for photosynthesis. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.