Cancer-derived exosomic microRNAs shape the immune system within the tumor microenvironment: State of the art.
Cancer-derived exosomic microRNAs shape the immune system within the tumor microenvironment: State of the art.
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DOI：
10.1016/j.semcdb.2016.12.004
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发表时间：
2017-07
影响因子：
7.3
通讯作者：
Fabbri M
中科院分区：
文献类型：
--
作者：
Fanini F;Fabbri M
近年来，科学界对外来体研究的兴趣越来越大，特别强调肿瘤来源的外来体促进肿瘤生长的机制。特别是，外泌体介导的免疫逃逸正在进行深入研究，并且仍然是一个颇具争议的问题。肿瘤来源的外泌体是能够重编程免疫靶细胞功能的信息载体，影响其发育、成熟和抗肿瘤活性。它们传递与亲本癌细胞相似的蛋白质，但也传递遗传信息，如基因组DNA、mRNA和microRNA（miRNAs），最终以促肿瘤方式共享所谓的“肿瘤微环境”。肿瘤来源的外泌体的含量可能涉及在肿瘤微环境中操作的几种信号传导途径，提供了抗肿瘤免疫失调的另一种模式。本文就肿瘤源性exosomic miRNAs与免疫系统细胞相互作用的最新研究进展作一综述。
In recent years there has been an increasing interest of the scientific community on exosome research, with particular emphasis on the mechanisms by which tumor-derived exosomes can promote tumor growth. Particularly, exosome-mediated immune-escape is under deep investigation and still represents a quite controversial issue. Tumor-derived exosomes are carriers of information able to reprogram functions of immune target cells, influencing their development, maturation, and antitumor activities. They deliver proteins similar to those of the parent cancer cells, but also genetic messages like genomic DNA, mRNA, and microRNAs (miRNAs) that ultimately share the so called “tumor microenvironment” in a pro-tumoral fashion. The content of tumor-derived exosomes could be implicated in several signaling pathways operating in the tumor microenvironment, providing a further modality of dys-regulation of antitumor immunity. The aim of this review is to provide a state-of-the-art highlight of to the most recent discoveries in the field of interaction between tumor-derived exosomic miRNAs and the cells of immune system.