Relationships between polysomnographic variables, parameters of glucose metabolism, and serum androgens in obese adolescents with polycystic ovarian syndrome
Relationships between polysomnographic variables, parameters of glucose metabolism, and serum androgens in obese adolescents with polycystic ovarian syndrome
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DOI：
10.1111/j.1365-2869.2010.00902.x
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发表时间：
2011-09-01
影响因子：
4.4
通讯作者：
Reinehr, Thomas
中科院分区：
文献类型：
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作者：
De Sousa, Gideon;Schlueter, Bernhard;Reinehr, Thomas
本研究的目的是比较多囊卵巢综合征（PCOS）的肥胖青少年的多导睡眠图变量与健康对照组的多导睡眠图变量，并分析多导睡眠图变量是否与体重/身体成分参数，血清雄激素和葡萄糖代谢参数相关。31例肥胖青少年多囊卵巢综合征（15.0岁+/- 1.0，体重指数32.7 kg/m2 +/- 6.2）和19名健康肥胖青少年，无PCOS（15.2岁+/- 1.1，体重指数32.4 kg/m2 +/- 4.0）进行多导睡眠图检查，比较呼吸暂停指数、呼吸不足指数、呼吸暂停-呼吸不足指数，阻塞性呼吸暂停的绝对数量、非快速眼动（NREM）睡眠的睡眠阶段1、2、3和4的百分比、REM睡眠的百分比、TIB、总睡眠时间（TST）、睡眠起始潜伏期、总觉醒时间（TWT）、睡眠起始后觉醒（WASO）和睡眠效率。此外，我们将多导睡眠图变量与体重/身体组成参数、血清雄激素和葡萄糖代谢参数相关。我们发现，两组之间的呼吸指数，睡眠的NREM睡眠阶段2，3和4，TIB和睡眠潜伏期的百分比没有差异。PCOS组与对照组在TST、WASO、TWT、睡眠效率、NREM睡眠第1阶段百分比和REM睡眠百分比方面存在显著差异。我们发现胰岛素抵抗和呼吸暂停指数之间以及胰岛素抵抗和呼吸暂停低通气指数之间存在弱的显著相关性。关于呼吸变量，PCOS青少年似乎与健康对照组没有差异;然而，睡眠结构似乎存在差异。
The aim of this study was to compare polysomnographic variables of obese adolescents with polycystic ovarian syndrome (PCOS) to those of healthy controls and to analyse whether polysomnographic variables correlate to parameters of body weight/body composition, to serum androgens and to parameters of glucose metabolism. Thirty-one obese adolescents with PCOS (15.0 years +/- 1.0, body mass index 32.7 kg per m(2) +/- 6.2) and 19 healthy obese adolescents without PCOS (15.2 years +/- 1.1, body mass index 32.4 kg per m(2) +/- 4.0) underwent polysomnography to compare apnoea index, hypopnoea index, apnoea-hypopnoea index, the absolute number of obstructive apnoeas, percentage sleep Stages 1, 2, 3 and 4 of non-rapid eye movement (NREM) sleep, percentage of REM sleep, TIB, total sleep time (TST), sleep-onset latency, total wake time (TWT), wakefulness after sleep onset (WASO) and sleep efficiency. Furthermore, we correlated polysomnographic variables to parameters of body weight/body composition, to serum androgens and to parameters of glucose metabolism. We found no differences between the two groups concerning the respiratory indices, percentage sleep Stages 2, 3 and 4 of NREM sleep, TIB and sleep-onset latency. The girls with PCOS differed significantly from the controls regarding TST, WASO, TWT, sleep efficiency, percentage Stage 1 of NREM sleep and percentage of REM sleep. We found a weak significant correlation between insulin resistance and apnoea index and between insulin resistance and apnoea-hypopnoea index. Concerning the respiratory variables, adolescents with PCOS do not seem to differ from healthy controls; however, there seem to be differences concerning sleep architecture.