ANAPLASTIC THYROID-CARCINOMA - A STUDY OF 70 CASES
ANAPLASTIC THYROID-CARCINOMA - A STUDY OF 70 CASES
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DOI：
10.1093/ajcp/83.2.135
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发表时间：
1985-01-01
影响因子：
3.5
通讯作者：
ROSAI, J
中科院分区：
文献类型：
--
作者：
CARCANGIU, ML;STEEPER, T;ROSAI, J
本文报告甲状腺未分化癌70例。三种形态：梭形，巨细胞和鳞片状，有时组合。超微结构上，在大多数但不是所有的情况下，上皮分化的证据。免疫组化，染色细胞角蛋白使用单克隆抗体是最有用的诊断辅助。癌胚抗原（CEA）意外阳性被发现在几个鳞状细胞肿瘤。未证实该肿瘤类型的甲状腺球蛋白和降钙素的频繁阳性。三分之一的肿瘤与分化较好的成分有关，据推测，它们代表了去分化。甲状腺未分化癌的极端侵袭性行为在该系列中得到证实：所有随访信息可用的患者均死于肿瘤。小细胞肿瘤不应被纳入间变性类别，因为它们总是属于其他组，即，恶性淋巴瘤、髓样癌和低分化（岛状）癌。
Cases (70) of anaplastic thyroid carcinomas were studied. Three morphologic patterns were seen: spindle, giant cell and squamoid, sometimes in combination. Ultrastructurally, evidence of epithelial differentiation was seen in most but not all cases. Immunohistochemically, a stain for cytokeratin using a monoclonal antibody was the most useful diagnosis adjunct. Unexpected positivity for carcinoembryonic antigen (CEA) was found in several squamoid tumors. The alleged frequent positivity of this tumor type for thyroglobulin and calcitonin was not confirmed. One-third of the tumors were associated with a better differentiated component, of which, presumably, they represented a dedifferentiation. The extremely aggressive behavior of anaplastic thyroid carcinomas was confirmed in this series: all of the patients in whom followup information was available died of their tumor. Small cell tumors should not be included into the anaplastic category, since they invariably belong to other groups, i.e., malignant lymphoma, medullary carcinoma and poorly differentiated (insular) carcinoma.