Follow the Metaplasia: Characteristics and Oncogenic Implications of Metaplasia's Pattern of Spread Throughout the Stomach.
Follow the Metaplasia: Characteristics and Oncogenic Implications of Metaplasia's Pattern of Spread Throughout the Stomach.
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DOI：
10.3389/fcell.2021.741574
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发表时间：
2021
影响因子：
5.5
通讯作者：
Sáenz JB
中科院分区：
文献类型：
--
作者：
Sáenz JB
人类胃既是消化器官，也是先天免疫器官。它的主要产品，酸，迅速分解摄入的产品，同样作为一个高效的微生物过滤器。胃上皮已经进化出适当处理无数外源性和内源性有害物质的机制，以维持上皮屏障并恢复稳态。胃必须面对的最重要的慢性损伤是幽门螺杆菌（Hp），这是一种胃适应性细菌，可以在胃中定植并诱导慢性炎症和肿瘤前变化。从慢性炎症到异型增生的进展依赖于这种癌细菌与其胃宿主之间长达数十年的相互作用。这篇综述总结了功能和分子区域化的胃在稳态和细节慢性炎症如何导致这些发展分界的特征性改变，无论是在地形和腺体水平。更重要的是，这篇综述说明了我们目前对癌前胃景观的上皮机制的理解，Hp如何适应和利用这些变化，以及识别这些变化的临床意义，以分层患者患胃癌的风险，胃癌是全球癌症相关死亡的主要原因。
The human stomach functions as both a digestive and innate immune organ. Its main product, acid, rapidly breaks down ingested products and equally serves as a highly effective microbial filter. The gastric epithelium has evolved mechanisms to appropriately handle the myriad of injurious substances, both exogenous and endogenous, to maintain the epithelial barrier and restore homeostasis. The most significant chronic insult that the stomach must face is Helicobacter pylori (Hp), a stomach-adapted bacterium that can colonize the stomach and induce chronic inflammatory and pre-neoplastic changes. The progression from chronic inflammation to dysplasia relies on the decades-long interplay between this oncobacterium and its gastric host. This review summarizes the functional and molecular regionalization of the stomach at homeostasis and details how chronic inflammation can lead to characteristic alterations in these developmental demarcations, both at the topographic and glandular levels. More importantly, this review illustrates our current understanding of the epithelial mechanisms that underlie the pre-malignant gastric landscape, how Hp adapts to and exploits these changes, and the clinical implications of identifying these changes in order to stratify patients at risk of developing gastric cancer, a leading cause of cancer-related deaths worldwide.
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影响因子：
9.8
作者：
Correa, Pelayo;Piazuelo, M. Blanca;Wilson, Keith T.
通讯作者：
Wilson, Keith T.
DOI：
10.1083/jcb.201301005
发表时间：
2013-04-15
期刊：
The Journal of cell biology
影响因子：
--
作者：
Romer AI;Singh J;Rattan S;Krauss RS
通讯作者：
Krauss RS
DOI：
10.23750/abm.v89i8-s.7946
发表时间：
2018-12-17
期刊：
Acta bio-medica : Atenei Parmensis
影响因子：
--
作者：
Crafa, Pellegrino;Russo, Michele;Di Mario, Francesco
通讯作者：
Di Mario, Francesco
影响因子：
9.8
作者：
Cassaro, M;Rugge, M;Genta, RM
通讯作者：
Genta, RM
影响因子：
16.6
作者：
Bauer M;Nascakova Z;Mihai AI;Cheng PF;Levesque MP;Lampart S;Hurwitz R;Pfannkuch L;Dobrovolna J;Jacobs M;Bartfeld S;Dohlman A;Shen X;Gall AA;Salama NR;Töpfer A;Weber A;Meyer TF;Janscak P;Müller A
通讯作者：
Müller A