A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting
A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting
复制标题
DOI：
10.1017/s0950268805004012
复制
发表时间：
2005-10-01
影响因子：
4.2
通讯作者：
Miller, E
中科院分区：
文献类型：
--
作者：
Hussain, M;Melegaro, A;Miller, E
2001年至2002年，在英国赫特福德郡，对学龄前儿童及其家庭进行了为期10个月的纵向家庭研究，每月访问一次，收集流行病学数据和鼻咽拭子。肺炎球菌培养采用标准方法。总共有121个家庭(489个人)参加了调查。0-2岁、3-4岁、5-17岁和18岁年龄组的平均携带率分别为52%、45%、21%和8%。在0-2岁的儿童中，86%的儿童发生过一次以上的携带，而在18岁的儿童中，这一比例为36%。0~2岁组最常见的血清型是6B型，其次是19F型、23F型、6A型和14型。红霉素耐药(单独或联合)占10%，青霉素不敏感占3(.)7%。总体而言，最近获得许可的7价结合疫苗对的血清型有保护作用，%的血清型没有血清群内交叉保护，82%的血清型有这种保护作用。在前结合疫苗时代的英国，鼻咽携带肺炎链球菌是很常见的。PCV对很大比例的携带性分离株具有保护作用。然而，需要监测疫苗接种对非疫苗血清型的影响。
A 10-month longitudinal household study of pre-school children and their families was undertaken with monthly visits collecting epidemiological data and nasopharyngeal swabs in Hertfordshire, England from 2001 to 2002. Pneumococcal culture was with standard methods. In total, 121 families (489 individuals) took part. Mean prevalence of carriage ranged from 52% for age groups 0-2 years, 45% for 3-4 years, 21% for 5-17 years and 8% for > 18 years. Carriage occurred more than once in 86% of children aged 0-2 years compared to 36% of those aged >= 18 years. The most prevalent serotypes in the 0-2 years age group were 6B followed by 19F, 23F, 6A and 14. Young children were responsible for the majority of introductions of new serotypes into a household. Erythromycin resistance (alone or in combination) occurred in 10% of samples and penicillin non-susceptibility in 3(.)7%. Overall the recently licensed 7-valent conjugate vaccine (PCV) would protect against 64% of serotypes with no intra-serogroup cross protection and 82% with such protection. Nasopharyngeal carriage of S. pneumoniae is common in a UK setting in the pre-conjugate vaccine era. PCV would protect against a large proportion of carriage isolates. However, the impact of vaccination on non-vaccine serotypes will need to be monitored.