AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch.
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch.
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DOI：
10.1038/ni.2187
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发表时间：
2011-11-20
影响因子：
30.5
通讯作者：
Colonna, Marco
中科院分区：
文献类型：
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作者：
Lee, Jacob S.;Cella, Marina;McDonald, Keely G.;Garlanda, Cecilia;Kennedy, Gregory D.;Nukaya, Manabu;Mantovani, Alberto;Kopan, Raphael;Bradfield, Christopher A.;Newberry, Rodney D.;Colonna, Marco
先天性淋巴样细胞（ILC）-22通过分泌白细胞介素-22（IL-22）保护肠粘膜免受感染。它们包括NKp 46+和类肉瘤组织诱导物（LTi）样亚群。两者都表达芳香烃受体（AHR），一种环境，饮食和内源性芳香化合物的传感器。我们发现，AHR-/-小鼠具有明显的ILC 22缺陷，导致IL-22分泌减少和对肠道细菌感染的保护不足。AHR-/-小鼠也缺乏出生后印记的隐痛斑（CP）和分离的淋巴滤泡（ILF），但没有胚胎印记的派伊尔斑（PP）。AHR诱导NKp 46 +ILC所需的Notch，而LTi样ILC、CP和ILF部分依赖于Notch信号传导。这些结果表明，AHR是必需的ILC 22和出生后的肠道淋巴组织，并揭示了异质性的ILC 22亚群在其发展的要求和他们对肠道淋巴组织的产生的影响。
Innate lymphoid cells (ILC)-22 protect the intestinal mucosa from infections by secreting interleukin-22 (IL-22). They include NKp46+ and Lymphoid Tissues inducer (LTi)-like subsets. Both express the aryl-hydrocarbon receptor (AHR), a sensor for environmental, dietary and endogenous aromatic compounds. We show that AHR-/- mice have a marked ILC22 deficit, resulting in diminished IL-22 secretion and inadequate protection against intestinal bacterial infections. AHR-/- mice also lack post-natally-imprinted cryptopatches (CP) and isolated lymphoid follicles (ILF), but not embryonically-imprinted Peyer's Patches (PP). AHR induces Notch, which is required for NKp46+ILC, while LTi-like ILC, CP and ILF are partially dependent on Notch signaling. These results establish that AHR is essential for ILC22 and post-natal intestinal lymphoid tissues and reveal heterogeneity of ILC22 subsets in their developmental requirements and their impact on the generation of intestinal lymphoid tissues.
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DOI：
10.4049/jimmunol.1003658
发表时间：
2011-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Keerthivasan S;Suleiman R;Lawlor R;Roderick J;Bates T;Minter L;Anguita J;Juncadella I;Nickoloff BJ;Le Poole IC;Miele L;Osborne BA
通讯作者：
Osborne BA
影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
32.4
作者：
Hughes T;Becknell B;Freud AG;McClory S;Briercheck E;Yu J;Mao C;Giovenzana C;Nuovo G;Wei L;Zhang X;Gavrilin MA;Wewers MD;Caligiuri MA
通讯作者：
Caligiuri MA
DOI：
10.1084/jem.20101330
发表时间：
2010-08-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Asquith M;Powrie F
通讯作者：
Powrie F