Results of a feasibility randomised controlled study of the guidelines for exercise in multiple sclerosis project
Results of a feasibility randomised controlled study of the guidelines for exercise in multiple sclerosis project
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DOI：
10.1016/j.cct.2016.11.012
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发表时间：
2017-03-01
影响因子：
2.2
通讯作者：
Motl, Robert W.
中科院分区：
文献类型：
--
作者：
Learmonth, Yvonne C.;Adamson, Brynn C.;Motl, Robert W.
越来越多的人认识到运动是管理多发性硬化症（MS）的许多后果的有效策略，但MS患者没有进行足够的运动以获得健康益处。运动摄取不足可能与先前研究的设计有关。我们进行了一项随机对照试验（RCP），以检查4个月的家庭为基础的运动训练计划的可行性，该计划是根据最近的MS体力活动指南设计的，并辅之以依从性行为策略。在工艺领域（例如，招聘），资源（例如，货币成本），管理（例如，人员时间要求）和科学成果（例如，治疗效果）。我们招募了轻度至中度MS患者，他们被随机分为干预组或等待名单对照组。干预参与者收到一个计步器，弹性阻力带，DVD，培训手册，日历，日志，视频辅导电话和时事通讯。两种情况下的参与者在4个月期间之前和之后完成了基于家庭的评估。99名MS患者接受了资格评估，57名患者接受了随机分组。51人完成了研究（90%）。研究的总费用为5331.03美元。人员进行研究的时间总计263小时。干预组的参与者完全遵守了71%的所有锻炼课程。通过Godin休闲时间锻炼问卷（d >= 0.5）测量，干预参与者自我报告的锻炼行为适度增加。结果支持基于体力活动指南并辅以轻度至中度MS成人行为策略的家庭运动干预的可行性和可接受性。All rights reserved.
There is increasing recognition that exercise is an efficacious strategy for managing many consequences of multiple sclerosis (MS), yet persons with MS are not engaging in sufficient exercise for accruing health benefits. Poor exercise uptake might be associated with the design of previous research. We conducted a randomised controlled trial (RCP) for examining the feasibility of a 4-month home-based, exercise-training program designed based on recent physical activity guidelines for MS and supplemented by behavioural strategies for compliance. Feasibility was assessed in the domains of process (e.g., recruitment), resource (e.g., monetary costs), management (e.g., personnel time requirements) and scientific outcomes (e.g., treatment effect). We recruited persons with mild-to-moderate MS who were randomised into an intervention or wait-list control condition. Intervention participants received a pedometer, elastic resistance bands, DVD, training inanual, calendars, log-book, video coaching calls and newsletters. Participants in both conditions completed home-based assessments before and after the 4-month period. Ninety-nine persons with MS were assessed for eligibility, and 57 were randomised. Fifty-one persons completed the study (90%). Total costs of the study were US $5331.03. Personnel time to conduct the study totaled 263 h. Participants in the intervention group complied fully with 71% of all exercise sessions. There was a moderate increase in self-reported exercise behaviour of the intervention participants as measured by the Godin Leisure-Time Exercise Questionnaire (d >= 0.5). The results support the feasibility and acceptability of a home-based exercise intervention based on physical activity guidelines and supplemented with behavioural strategies for adults with mild-to-moderate MS. (C) 2016 Elsevier Inc. All rights reserved.