Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis
Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis
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DOI：
10.1016/j.atherosclerosis.2009.05.036
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发表时间：
2009-12-01
期刊：
影响因子：
5.3
通讯作者：
Williams, M. J. A.
中科院分区：
文献类型：
--
作者：
Jones, G. T.;Tarr, G. P.;Williams, M. J. A.
目的：探讨新西兰裸金属支架置入术患者血浆活性基质金属蛋白酶(MMPs)水平与支架内再狭窄(ISR)的关系。方法：对152例有支架内再狭窄病史的患者和151例支架术后1年无症状患者(Non-ISR)进行比较。收集人口学和血管造影特征。采用酶联免疫吸附试验检测血浆中基质金属蛋白酶-1、-2、-3和-9的活性形式以及金属蛋白酶组织抑制物-1的表达。结果：活性的基质金属蛋白酶-9和活性的基质金属蛋白酶-3与ISR的病史独立相关。升高的活性基质金属蛋白酶-3和-9水平调整后的优势比为11.8(95%CI：4-35，p<；0.0001)，37%的ISR患者有这样的水平，而非ISR患者为11%。这两种基质金属蛋白酶生物标志物的加入显著增加了结合了显著的人口统计学和血管造影变量的受试者操作员特征分析的曲线下面积(AuC0.85vs.0.78，p<；0.005)。结论：血浆活性基质金属蛋白酶亚型的测量似乎与ISR独立相关，多个基质金属蛋白酶标志物的评估产生累积实用价值。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
Objective: This study aimed to determine whether plasma levels of active matrix metalloproteinases (MMP) are predictors of in-stent restenosis (ISR) in New Zealand patients treated with bare-metal coronary stents.Methods: A group of 152 patients with a history of ISR were compared with 151 symptom free 1-year post-stenting patients (non-ISR). Demographic and angiographic characteristics were collected. Plasma samples were analyzed for the active forms of MMP-1, -2, -3 and -9 as well as tissue inhibitor of metalloproteinases (TIMP-1) using ELISA-based isoform sensitive assays.Results: Both active MMP-9 and active MMP-3 were independently associated with history of ISR. Elevated levels of both active MMP-3 and -9 had an adjusted odds ratio of 11.8 (95% CI: 4-35, p < 0.0001) for association with ISR, with 37% of ISR patients having such levels versus 11% on non-ISR. The addition of both of the MMP biomarkers significantly increased the area under the curve (AUC) of a receiver operator characteristic (ROC) analysis incorporating the significant demographic and angiographic variables ( AUC 0.85 versus 0.78, p < 0.005).Conclusion: Measures of plasma active MMP isoforms appear to be independently associated with ISR, and assessment of multiple MMP markers yields cumulative utility. (c) 2009 Elsevier Ireland Ltd. All rights reserved.