EFFECT OF AGING ON CEREBRAL-CORTEX ENERGY-METABOLISM IN HYPOGLYCEMIA AND POSTHYPOGLYCEMIC RECOVERY
EFFECT OF AGING ON CEREBRAL-CORTEX ENERGY-METABOLISM IN HYPOGLYCEMIA AND POSTHYPOGLYCEMIC RECOVERY
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DOI：
10.1016/0197-4580(84)90064-2
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发表时间：
1984-01-01
影响因子：
4.2
通讯作者：
GIUFFRIDA, AM
中科院分区：
文献类型：
--
作者：
BENZI, G;PASTORIS, O;GIUFFRIDA, AM
Severe hypoglycemia causing the cessation of spontaneous EEG, induced in cerebral cortex of rats of different ages, causes gross energy failure and extensive derangement of both carbohydrate and amino acid contents. During posthypoglycemic recovery of adult rats, there was moderate restitution of energy metabolism and both ATP concentration and adenine nucleotide pool remained still reduced, even if the creatine phosphate and ADP contents were close to normal. During recovery of adult rats, there was a rise in glutamate and glutamine concentrations; and the perturbated aspartate and gamma-aminobutyrate cerebral contents were normalized. Ammonia content decreased to normal, while alanine content was markedly elevated. Aging does not affect the cerebral metabolic derangements occurring in severe hypoglycemia, but rather the metabolic changes that the brain tend to reverse during the posthypoglycemic restitution. There was lower restitution of the contents of cerebral cortical metabolities of mature and senescent rats in comparison with adult ones. In older brains the contents of many amino acids and adenylate nucleotides remained largely abnormal.
