Effect of autologous bone-marrow cell transplantation on ischemic ulcer in patients with Buerger's disease
Effect of autologous bone-marrow cell transplantation on ischemic ulcer in patients with Buerger's disease
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DOI：
10.1253/circj.71.1187
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发表时间：
2007-08-01
影响因子：
3.3
通讯作者：
Imaizumi, Tsutomu
中科院分区：
文献类型：
--
作者：
Saito, Yutaka;Sasaki, Ken-ichiro;Imaizumi, Tsutomu
血栓闭塞性脉管炎，也称为Buerger病，其特征在于上下肢动脉的外周闭塞性改变，治疗通常无效。最近有报道称，自体骨髓单个核细胞（BM-MNC）肌内移植可改善严重缺血肢体患者的症状和临床表现，主要由动脉硬化闭塞症引起。本研究的重点是与Buerger病的患者表现为静息痛和/或皮肤溃疡不受控制的常规treatment.Methods和结果14例Buerger病（方丹III：n=2，方丹IV：n= 12）进行自体骨髓单个核细胞移植到缺血骨骼肌的上肢或下肢。4周后，静息痛明显减轻。9例19处皮肤溃疡中，8处愈合，8处缩小。结论在Buerger病患者中，自体BM-MNC肌肉内移植可改善症状和临床表现，尤其是皮肤溃疡。
Background Thromboangiitis obliterans, also known as Buerger's disease, is characterized by peripheral occlusive changes in the arteries of the upper and lower limbs and treatment is often ineffective. Intramuscular transplantation of autologous bone marrow-mononuclear cells (BM-MNC) has been recently reported as improving the symptoms and clinical manifestations in patients with severely ischemic limbs, mostly caused by arteriosclerosis obliterans. The present study focused on the patients with Buerger's disease presenting with rest pain and/or skin ulcer uncontrolled by conventional treatments.Methods and Results Fourteen patients with Buerger's disease (Fontaine III: n=2, Fontaine IV: n= 12) underwent transplantation of autologous BM-MNC into ischemic skeletal muscles of either the upper or lower limb. After 4 weeks, rest pain was significantly reduced. In 19 skin ulcers of 9 patients, 8 ulcers were healed and 8 were diminished in the size. These improvements were maintained for 24 weeks without complications.Conclusions In patients with Buerger's disease, intramuscular transplantation of autologous BM-MNC improved symptoms and clinical manifestations, especially skin ulcer.