Golgi linked protein glycosylation and associated diseases.
Golgi linked protein glycosylation and associated diseases.
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DOI：
10.1016/j.semcdb.2009.03.004
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发表时间：
2009-09
影响因子：
7.3
通讯作者：
D. Ungar
中科院分区：
文献类型：
--
作者：
D. Ungar
高尔基体的主要功能之一是分泌蛋白的糖基化。高尔基体中可以合成多种聚糖链，并且越来越清楚的是，这些链对于基本细胞功能以及多细胞生物的发育至关重要。结构上记录最齐全的聚糖是 N-聚糖，但它们的功能也是最神秘的。相比之下，O-聚糖的功能得到了更好的理解，但其结构和生物合成途径非常不完整。聚糖与多种疾病相关，例如许多遗传性疾病，以及癌症或糖尿病，凸显了聚糖的至关重要性。然而，这些的分子线索才刚刚被阐明。尽管已知一些聚糖结构参与信号传导或与细胞外基质的粘附，但大多数功能尚不清楚。本次审查旨在总结当前的知识，并指出未来进展的关键领域。
One of the Golgi's main functions is the glycosylation of secreted proteins. A large variety of glycan chains can be synthesized in the Golgi, and it is increasingly clear that these are critical in basic cellular functions as well as the development of multicellular organisms. The structurally best-documented glycans are N-glycans, yet these are also the most enigmatic in their function. In contrast, O-glycan function is far better understood, but here the structures and biosynthetic pathways are very incomplete. The critical importance of glycans is highlighted by the broad spectrum of diseases they are associated with, such as a number of inherited diseases, but also cancers or diabetes. The molecular clues to these, however, are only just being elucidated. Although some glycan structures are known to be involved in signaling or adhesion to the extracellular matrix, for most the functions are not yet known. This review aims at summarizing current knowledge as much as to point out critical areas key for future progress.