Impact of histological subtype on survival of patients with surgically-treated stage IA2-IIB cervical cancer: Adenocarcinoma versus squamous cell carcinoma
Impact of histological subtype on survival of patients with surgically-treated stage IA2-IIB cervical cancer: Adenocarcinoma versus squamous cell carcinoma
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DOI：
10.1016/j.ygyno.2012.06.021
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发表时间：
2012-10-01
影响因子：
4.7
通讯作者：
Kimura, Tadashi
中科院分区：
文献类型：
--
作者：
Mabuchi, Seiji;Okazawa, Mika;Kimura, Tadashi
目标。目的：评价腺癌(AC)与鳞癌(SCC)对早期宫颈癌患者手术后生存率的影响。我们回顾了1998年1月至2008年12月间接受根治性子宫切除加或不加辅助放射治疗的520例FIGO期IA2-IIB期宫颈癌患者的病历。根据(I)病理危险因素(低、中、高风险组)和(Ii)辅助放疗(同步放化疗组或单纯放疗组)对患者进行分类。生存结果采用Kaplan-Meier方法，并与Log-ranch检验进行比较。采用COX比例风险回归模型进行疾病特异性生存(DSS)多因素分析，以探讨组织学亚型的预后意义。结果：与鳞癌组织学类型相比，中危组和高危组患者的DSS显著降低(风险比分别为3.06和2.88，P
Objectives. To evaluate the significance of adenocarcinoma (AC) compared with squamous cell carcinoma (SCC) with regard to the survival of surgically-treated early stage cervical cancer patients.Methods. We retrospectively reviewed the medical records of 520 patients with FIGO stage IA2-IIB cervical cancer who were treated with radical hysterectomy with or without adjuvant radiotherapy between January 1998 and December 2008. The patients were classified according to (i) pathological risk factors (low-, intermediate-, or high-risk group) and (ii) adjuvant radiotherapy (concurrent chemoradiotherapy [CCRT group] or radiotherapy alone [RT group]). Survival outcomes were examined by Kaplan-Meier method and compared with Log-rank test Multivariate analysis for disease-specific survival (DSS) was performed using Cox proportional hazards regression model to investigate the prognostic significance of histological subtype.Results: AC histology was associated with significantly decreased DSS compared with SCC histology in the intermediate- and high-risk groups (hazard ratio: 3.06 and 2.88, respectively, both P