Mechanisms of the respiratory activity of leptin at the level of the solitary tract nucleus.
Mechanisms of the respiratory activity of leptin at the level of the solitary tract nucleus.
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DOI：
10.1007/s11055-010-9316-2
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发表时间：
2010-09-01
影响因子：
--
通讯作者：
Inyushkin, A N
中科院分区：
文献类型：
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作者：
Inyushkina, E M;Merkulova, N A;Inyushkin, A N
在麻醉大鼠的急性实验中，观察了孤束核内微量注射10（-4）M瘦素对高碳酸血症引起的赫-布膨胀反射的影响。局部给药瘦素进入这一领域导致抑制Hering-Breuer反射。相反，高碳酸血症的缓解反应的程度增加，这可能提供证据表明，瘦素对中枢化学感受器具有调节作用。这些生理机制的行动可能发挥主导作用，在介导的刺激呼吸作用的瘦素在孤束核的水平。
Acute experiments on anesthetized laboratory rats were performed to study the effects microinjections of 10(-4) M leptin into the solitary tract nucleus on the extent of the Hering-Breuer inflation reflex in ventilatory reactions to hypercapnia. Local administration of leptin into this area led to inhibition of the Hering-Breuer reflex. The extent of ventilatory responses to hypercapnia, conversely, increased, which may provide evidence that leptin has a modulatory influence on central chemoreceptors. These physiological mechanisms of action probably play a leading role in mediating the stimulatory respiratory effects of leptin at the level of the solitary tract nucleus.