The Filamentous Phage Genome: Genes, Physical Structure, and Protein Products
The Filamentous Phage Genome: Genes, Physical Structure, and Protein Products
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丝状噬菌体基因组：基因、物理结构和蛋白质产物
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发表时间：
1978
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通讯作者：
P. Model
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作者：
K. Horiuchi;G. Vovis;P. Model
在本文中，我们回顾了丝状噬菌体基因组和噬菌体特异性蛋白质产物的组织。针对携带 F 因子的大肠杆菌菌株特异的丝状噬菌体，人们已经进行了大量的工作。这一类别包括 f1 (Loeb 1960; Zinder et al. 1963)、fd (Marvin and Hoffmann-Berling 1963)、M13 (Hofschneider 1963) 和 ZJ/2 (Bradley 1964)。这些噬菌体密切相关，我们通常不会区分它们。其他丝状噬菌体，包括大肠杆菌的 I 特异性噬菌体（Meynell 和 Lawn 1968）和假单胞菌的丝状噬菌体（Minamishima 等人，1968），已被描述，但不包括在本讨论中。我们描述了丝状噬菌体各种突变体的特性、基因在遗传和物理图谱上的组织以及基因组中的可甲基化碱基。我们还列出了基因产物并描述了它们的一些特性，并讨论了基因表达控制的各个方面。突变体条件致死丝状噬菌体的最初遗传学研究是由普拉特和他的同事（1966年的同事（1969））进行的，他们收集了琥珀和温度敏感的突变体，并通过标准互补分析将它们分为八个互补组。此后没有鉴定出其他基因。在普拉特收集中，基因VIII仅由一个条件致死突变代表，即am 8H1，并且其他研究丝状噬菌体的小组都没有鉴定出任何其他基因。基因 VIII 中的条件致死突变由于图谱未饱和，...
In this article we review the organization of the filamentous phage genome and the phage-specific protein products. A great deal of work has been done on the filamentous phages specific to strains of Escherichia coli carrying an F factor. Included in this category are f1 (Loeb 1960; Zinder et al. 1963), fd (Marvin and Hoffmann-Berling 1963), M13 (Hofschneider 1963), and ZJ/2 (Bradley 1964). These phages are so closely related that we will not usually distinguish among them. Other filamentous phages, including the I-specific phages of E. coli (Meynell and Lawn 1968) and the filamentous phages of Pseudomonas (Minamishima et al. 1968), have been described but are not included in this discussion. We describe the properties of the various mutants of the filamentous phages, the organization of the genes on the genetic and physical maps, and the methylatable bases in the genome. We also list the gene products and describe some of their properties, as well as discuss aspects of the control of gene expression. MUTANTS Conditional Lethals Initial genetic studies of the filamentous phages were carried out by Pratt and his colleagues (1966 colleagues (1969), who collected amber and temperature-sensitive mutants and classified them by standard complementation analysis into eight complementation groups. No additional genes have been identified since. In the Pratt collection, gene VIII is represented by only one conditionally lethal mutation, am 8H1, and none of the other groups working with the filamentous phages have identified any other conditionally lethal mutations in gene VIII. Since the map is not saturated,...