Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and non-fatal cardiovascular events, and mortality in men aged 17-97 years
Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and non-fatal cardiovascular events, and mortality in men aged 17-97 years
复制标题
DOI：
10.1111/cen.13089
复制
发表时间：
2016-10-01
影响因子：
3.2
通讯作者：
Yeap, Bu B.
中科院分区：
文献类型：
--
作者：
Chan, Yi X.;Knuiman, Matthew W.;Yeap, Bu B.
背景 较低的睾酮 (T) 与老年男性较差的健康结果相关，然而，T、二氢睾酮 (DHT) 和雌二醇 (E2) 与年轻至中年男性心血管疾病 (CVD) 之间的关系仍不清楚。 目的 我们在一组 17-97 岁的男性中评估了内源性激素与死亡率（全因和 CVD）和 CVD 事件之间的关联。 参与者和方法 检测了性激素对 1994 年 5 月巴瑟尔顿健康调查中的 2143 名男性进行了质谱分析。对截至 2010 年 12 月的结果进行了分析。 结果 在分析中纳入的 1804 名男性中，平均年龄为 50.3 +/- 16.8 岁，其中 68.9% 的男性老年
Context Lower testosterone (T) is associated with poorer health outcomes in older men, however, the relationship between T, dihydrotestosterone (DHT) and estradiol (E2) with cardiovascular disease (CVD) in younger to middle-aged men remains unclear.Objectives We assessed associations between endogenous sex hormones with mortality (all-cause and CVD) and CVD events, in a cohort of men aged 17-97 years.Participants and methods Sex hormones were assayed using mass spectrometry in 2143 men from the 1994/5 Busselton Health Survey. Outcomes to December 2010 were analysed.Results Of the 1804 men included in the analysis, mean age was 50.3 +/- 16.8 years and 68.9% of men were aged