Influence of individual and combined healthy behaviours on successful aging
Influence of individual and combined healthy behaviours on successful aging
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DOI：
10.1503/cmaj.121080
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发表时间：
2012-12-11
影响因子：
14.6
通讯作者：
Kivimaki, Mika
中科院分区：
文献类型：
--
作者：
Sabia, Severine;Singh-Manoux, Archana;Kivimaki, Mika
背景：预期寿命的增加使尽可能长时间保持健康变得重要。我们的目标是检查在何种程度上健康的行为在中年，单独和组合，预测成功的aging.Methods：我们采用了前瞻性队列设计，涉及5100名男性和女性年龄在42-63岁。参与者在1991-1994年作为白厅II研究的一部分评估他们的健康行为时没有癌症，冠状动脉疾病和中风。我们将健康行为定义为从不吸烟，适度饮酒，身体活动（>= 2.5小时/周中度身体活动或>= 1小时/周剧烈身体活动），以及每天吃水果和蔬菜。我们定义的成功老龄化，测量超过中位数16.3年的后续行动，良好的认知，身体，呼吸和心血管功能，除了没有残疾，心理健康问题和慢性疾病（冠状动脉疾病，中风，癌症和糖尿病）。与没有健康行为的参与者相比，参与所有4种健康行为的参与者成功衰老的几率高3.3倍（95%置信区间[CI] 2.1-5.1）。与成功老龄化的相关性是线性的，每增加一项健康行为的比值比（OR）为1.3（95%CI 1.2-1.4; 1-4 v. 0健康行为的人群归因风险为47%）。当缺失的数据被认为是在分析中，结果是相似的，我们的主要analysis.Interpretation：虽然个人的健康行为是适度与成功的老龄化，其综合影响是巨大的。我们没有调查这些关联背后的机制，但我们看到了健康行为对成功衰老的重要性的明确证据。
Background: Increases in life expectancy make it important to remain healthy for as long as possible. Our objective was to examine the extent to which healthy behaviours in midlife, separately and in combination, predict successful aging.Methods: We used a prospective cohort design involving 5100 men and women aged 42-63 years. Participants were free of cancer, coronary artery disease and stroke when their health behaviours were assessed in 1991-1994 as part of the Whitehall II study. We defined healthy behaviours as never smoking, moderate alcohol consumption, physical activity (>= 2.5 h/wk moderate physical activity or >= 1 h/wk vigorous physical activity), and eating fruits and vegetables daily. We defined successful aging, measured over a median 16.3-year follow-up, as good cognitive, physical, respiratory and cardiovascular functioning, in addition to the absence of disability, mental health problems and chronic disease (coronary artery disease, stroke, cancer and diabetes).Results: At the end of follow-up, 549 participants had died and 953 qualified as aging successfully. Compared with participants who engaged in no healthy behaviours, participants engaging in all 4 healthy behaviours had 3.3 times greater odds of successful aging (95% confidence interval [CI] 2.1-5.1). The association with successful aging was linear, with the odds ratio (OR) per increment of healthy behaviour being 1.3 (95% CI 1.2-1.4; population-attributable risk for 1-4 v. 0 healthy behaviours 47%). When missing data were considered in the analysis, the results were similar to those of our main analysis.Interpretation: Although individual healthy behaviours are moderately associated with successful aging, their combined impact is substantial. We did not investigate the mechanisms underlying these associations, but we saw clear evidence of the importance of healthy behaviours for successful aging.