A Regime Map for Granule Formation by Drop Impact on Powder Beds
A Regime Map for Granule Formation by Drop Impact on Powder Beds
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DOI：
10.1002/aic.13952
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发表时间：
2013-01-01
期刊：
影响因子：
3.7
通讯作者：
Litster, James D.
中科院分区：
文献类型：
--
作者：
Emady, Heather N.;Kayrak-Talay, Defne;Litster, James D.
“隧穿”、“扩散”和“形成陨石坑”是已知的单滴撞击静态粉床时发生的三种颗粒形成机制。为了量化每种机制发生的条件，进行了量纲分析，并创建了新的区域图，绘制了粉末床孔隙率与修正的颗粒键数(Bo*(G))的关系图，Bo*(G)是毛细管力与作用在颗粒上的重力的比率。对于所有床层孔隙度，Bo*(G)和Gt；65,000都发生了隧穿，而当Bo*(G)和Lt；65,000对于所有床层孔隙度低于最小流态化孔隙度时，则发生了铺展和凹坑的形成。颗粒形成机制区域图通过预测颗粒形成机理，从而预测颗粒的总体形状，从而为设计和预测湿法制粒过程提供了有用的工具，这些无量纲基团涉及配方特性和工艺参数，可以通过先验计算得到。(C)2012美国化学工程师学会学报，59：96-107,2013
"Tunneling,'' "Spreading,'' and "Crater Formation'' are the three granule formation mechanisms known to occur when single drops impact static powder beds. To quantify the conditions under which each mechanism will occur, dimensional analysis was performed, and a new regime map was created that plots the powder bed porosity against the modified granular Bond number (Bo*(g)), which is a ratio of the capillary force to the gravitational force acting on a particle. Tunneling occurred for Bo*(g) > 65,000 for all values of bed porosity, whereas Spreading and Crater Formation occurred when Bo*(g) < 65,000 for all values of bed porosity below the minimum fluidization porosity. The granule formation mechanism regime map provides a useful tool to design and predict wet granulation processes by predicting the granule formation mechanism, and thereby general granule shape, from a few key dimensionless groups involving formulation properties and process parameters that can be calculated a priori. (C) 2012 American Institute of Chemical Engineers AIChE J, 59: 96-107, 2013