Concomitant Psychiatric and Nonalcohol-Related Substance Use Disorders Among Hospitalized Patients with Alcoholic Liver Disease in the United States.
Concomitant Psychiatric and Nonalcohol-Related Substance Use Disorders Among Hospitalized Patients with Alcoholic Liver Disease in the United States.
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在美国，住院患者的酒精性肝病患者中，伴随精神病和非酒精相关药物使用障碍。
DOI：
10.1111/acer.13567
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium
中科院分区：
文献类型：
--
作者：
Jinjuvadia R;Jinjuvadia C;Puangsricharoen P;Chalasani N;Crabb DW;Liangpunsakul S;Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium
尽管关于酒精滥用和精神障碍共病的流行病学研究已经被研究过，但对酒精性肝病(ALD)患者中这些疾病的严重程度知之甚少。我们的目的是确定在美国住院的ALD患者中精神和物质使用障碍的患病率。我们利用单级临床分类软件从2011年全国住院患者样本数据中识别出ALD患者和精神/物质使用障碍患者。主要结果是，与非酒精引起的慢性肝病患者(350,140)和没有潜在肝病的患者(1,447,063)相比，这些疾病在住院的ALD患者(n=74,972)中的患病率。与非酒精引起的慢性肝病患者相比，ALD住院患者的适应障碍、焦虑障碍、创伤后应激障碍和抑郁的患病率显著升高(均为p值<；0.05)。年龄较小、女性和白人是ALD住院患者精神/物质使用障碍的独立预测因素。与非酒精引起的慢性肝病患者和没有潜在肝病的患者相比，ALD住院患者伴发精神障碍和药物滥用障碍的患病率明显较高。筛查和适当的干预措施应作为这些患者常规临床护理的一部分。
Despite that the epidemiological studies on the comorbidity of alcohol misuse and psychiatric disorders have been studied, less is known about the magnitude of these disorders among patients with alcoholic liver disease (ALD). Our aim was to determine the prevalence of psychiatric and substance use disorders among hospitalized ALD patients in the US. We utilized a single level clinical classification software to identify patients with ALD and psychiatric/substance use disorders from the 2011 National Inpatient Sample data. The primary outcome was the prevalence of these disorders among hospitalized patients with ALD (n=74,972) compared to those with chronic liver diseasesnot caused by alcohol (n=350,140) and those without underlying liver diseases (n=1,447,063). The prevalence of adjustment disorder, anxiety disorder, post-traumatic stress disorder and depression was significantly higher among hospitalized patients with ALD when compared to those with chronic liver diseases not caused by alcohol (all with p values <0.05). Younger age, female gender, and White race were the independent predictors of psychiatric/substance use disorders among hospitalized patients with ALD. Hospitalized patients with ALD have significantly high prevalence of concomitant psychiatric and substance abuse disorders when compared to those with chronic liver diseases not caused by alcohol and those without underlying liver diseases. Screening and appropriate intervention should be implemented as part of routine clinical care for these patients.
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影响因子：
25.7
作者：
Veldt, BJ;Lainé, F;Moirand, R
通讯作者：
Moirand, R
影响因子：
168.9
作者：
TELI, MR;DAY, CP;JAMES, OFW
通讯作者：
JAMES, OFW
影响因子：
4.6
作者：
Cuadrado, A;Fábrega, E;Pons-Romero, F
通讯作者：
Pons-Romero, F
DOI：
10.15288/jsa.1988.49.219
发表时间：
1988-05-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
HELZER, JE;PRYZBECK, TR
通讯作者：
PRYZBECK, TR
影响因子：
4.6
作者：
Dew, Mary Amanda;DiMartini, Andrea F.;Greenhouse, Joel
通讯作者：
Greenhouse, Joel